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Ddx58 (NM_172689) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR226477L4V
- LentiORF®
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Lenti ORF particles, Ddx58 (GFP-tagged) - Mouse DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (Ddx58), 200ul, >10^7 TU/mL
Mouse Protein / Lysate Request
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CNY 15,960.00
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规格
| Cited in 1 publication. |
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经常一起买 (3)
Specifications
| Product Data | |
| Product Name | Ddx58 (NM_172689) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 6430573D20Rik; C330021E21; RIG-I; RLR-1 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_172689 |
| ORF Size | 2778 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR226477).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_172689.3, NP_766277.3 |
| RefSeq Size | 4943 bp |
| RefSeq ORF | 2781 bp |
| Locus ID | 230073 |
| Gene Summary | Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: newcastle disease virus (NDV) and Sendai virus (SeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV). It also detects rotavirus and orthoreovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration.[UniProtKB/Swiss-Prot Function] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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RIG-I Promotes Cell Death in Hepatocellular Carcinoma by Inducing M1 Polarization of Perineal Macrophages Through the RIG-I/MAVS/NF-κB Pathway
,Zhou, B;Li, C;Yang, Y;Wang, Z;,
OncoTargets and therapy
,PubMed ID 32982277
[DDX58]
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