Ptpn22 (NM_008979) Mouse Tagged ORF Clone Lentiviral Particle

CAT＃: MR210734L4V

  • LentiORF®

Lenti ORF particles, Ptpn22 (GFP-tagged) - Mouse protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (Ptpn22), 200ul, >10^7 TU/mL

ORF Plasmid: DDK tGFP

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CNY 14,345.00

货期*
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规格
    • 200 ul

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Specifications

Product Data
Product Name Ptpn22 (NM_008979) Mouse Tagged ORF Clone Lentiviral Particle
Synonyms 70zpep; PEP; Ptpn8
Vector pLenti-C-mGFP-P2A-Puro
ACCN NM_008979
ORF Size 2406 bp
Sequence Data
The ORF insert of this clone is exactly the same as(MR210734).
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq NM_008979.1, NP_033005.1
RefSeq Size 2734 bp
RefSeq ORF 2409 bp
Locus ID 19260
Gene Summary Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (By similarity). Associates with and probably dephosphorylates CBL (By similarity). Dephosphorylates LCK at its activating 'Tyr-394' residue (By similarity). Dephosphorylates ZAP70 at its activating 'Tyr-492' residue (By similarity). Dephosphorylates the immune system activator SKAP2 (By similarity). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (PubMed:23871208). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106).[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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