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Mfn2 (NM_133201) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR210494L3V
- LentiORF®
-
Lenti ORF particles, Mfn2 (Myc-DDK-tagged) - Mouse mitofusin 2 (Mfn2), nuclear gene encoding mitochondrial protein, 200ul, >10^7 TU/mL
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CNY 12,445.00
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| Product Data | |
| Product Name | Mfn2 (NM_133201) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | D630023P19Rik; Fzo |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_133201 |
| ORF Size | 2274 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR210494).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_133201.2, NP_573464.2 |
| RefSeq Size | 4476 bp |
| RefSeq ORF | 2274 bp |
| Locus ID | 170731 |
| Gene Summary | Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12527753, PubMed:23921378, PubMed:23620051). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks. Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (By similarity). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (PubMed:23921556). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (PubMed:23921556).[UniProtKB/Swiss-Prot Function] |
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