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Xrcc5 (NM_009533) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR210341L4V
- LentiORF®
-
Lenti ORF particles, Xrcc5 (GFP-tagged) - Mouse X-ray repair complementing defective repair in Chinese hamster cells 5 (Xrcc5), 200ul, >10^7 TU/mL
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CNY 13,585.00
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Specifications
| Product Data | |
| Product Name | Xrcc5 (NM_009533) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AI314015; CTC85; CTCBF; Ku80; Ku86 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_009533 |
| ORF Size | 2196 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR210341).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_009533.2, NP_033559.2 |
| RefSeq Size | 2571 bp |
| RefSeq ORF | 2199 bp |
| Locus ID | 22596 |
| Gene Summary | Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NAA15, the XRCC5/6 dimer binds to the osteocalcin promoter and activates osteocalcin expression. The XRCC5/6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.[UniProtKB/Swiss-Prot Function] |
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