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Creb3l1 (NM_011957) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR208154L4V
- LentiORF®
-
Lenti ORF particles, Creb3l1 (GFP-tagged) - Mouse cAMP responsive element binding protein 3-like 1 (Creb3l1), 200ul, >10^7 TU/mL
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CNY 10,925.00
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Specifications
| Product Data | |
| Product Name | Creb3l1 (NM_011957) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | Oasis |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_011957 |
| ORF Size | 1563 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR208154).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_011957.2, NP_036087.2 |
| RefSeq Size | 2284 bp |
| RefSeq ORF | 1563 bp |
| Locus ID | 26427 |
| Gene Summary | Transcription factor involved in unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (By similarity). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues, such as skin (PubMed:19767743). Required to protect astrocytes from ER stress-induced cell death. In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation (PubMed:15665855). Inhibits cell-cycle progression by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A (By similarity). Required for TGFB1 to activate genes involved in the assembly of collagen extracellular matrix (By similarity).[UniProtKB/Swiss-Prot Function] |
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