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Smad3 (NM_016769) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR206770L4V
- LentiORF®
-
Lenti ORF particles, Smad3 (GFP-tagged) - Mouse MAD homolog 3 (Drosophila) (Smad3), 200ul, >10^7 TU/mL
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CNY 8,360.00
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Specifications
| Product Data | |
| Product Name | Smad3 (NM_016769) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AU022421; Madh3 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_016769 |
| ORF Size | 1278 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR206770).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_016769.2 |
| RefSeq Size | 5090 bp |
| RefSeq ORF | 1278 bp |
| Locus ID | 17127 |
| Gene Summary | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity).[UniProtKB/Swiss-Prot Function] |
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