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Cish (NM_009895) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR203328L3V
- LentiORF®
-
Lenti ORF particles, Cish (Myc-DDK-tagged) - Mouse cytokine inducible SH2-containing protein (Cish), 200ul, >10^7 TU/mL
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CNY 7,410.00
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Specifications
| Product Data | |
| Product Name | Cish (NM_009895) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | Cis; CIS-1; CIS1; F17; F23; SOCS |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_009895 |
| ORF Size | 774 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR203328).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_009895.3 |
| RefSeq Size | 2161 bp |
| RefSeq ORF | 774 bp |
| Locus ID | 12700 |
| Gene Summary | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).[UniProtKB/Swiss-Prot Function] |
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