United States
Germany
Japan
United Kingdom
China
Rpa3 (NM_026632) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR200594L4V
- LentiORF®
-
Lenti ORF particles, Rpa3 (GFP-tagged) - Mouse replication protein A3 (Rpa3), 200ul, >10^7 TU/mL
Mouse Protein / Lysate Request
Need custom lentivirus service?
Get a free quote
CNY 8,360.00
货期*
详询
规格
Product images
经常一起买 (2)
Specifications
| Product Data | |
| Product Name | Rpa3 (NM_026632) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 14kDa; C330026P08Rik |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_026632 |
| ORF Size | 366 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR200594).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_026632.1 |
| RefSeq Size | 655 bp |
| RefSeq ORF | 366 bp |
| Locus ID | 68240 |
| Gene Summary | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin, in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER), probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA3 has its own single-stranded DNA-binding activity and may be responsible for polarity of the binding of the complex to DNA.[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
You may also need
Customer
Reviews
Loading...
