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THOC5 (NM_001002878) Human Untagged Clone
CAT＃: SC320623
THOC5 (untagged)-Human THO complex 5 (THOC5), transcript variant 1
CNY 5,008.00
CNY 7,220.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | C22orf19; Fmip; fSAP79; PK1.3 |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene sequence for NM_001002878.1
GTTCTTGGAGCTGTGAGGAGGAACAACCATGTCATCAGAATCGAGCAAAAAACGGAAGCC
CAAAGTGATCCGAAGCGATGGAGCCCCAGCTGAAGGAAAGCGGAATCGATCTGACACCGA GCAGGAAGGTAAATACTACAGTGAGGAGGCCGAGGTGGATCTGCGGGACCCTGGCAGAGA CTATGAGTTATACAAGTACACCTGCCAGGAGCTACAGAGGCTGATGGCTGAGATCCAAGA CCTGAAGAGCAGGGGTGGCAAGGATGTGGCAATAGAAATAGAAGAACGGAGGATCCAGAG CTGTGTGCATTTCATGACTCTAAAGAAGCTTAACCGATTAGCCCACATCAGGTTGAAGAA AGGAAGAGATCAGACCCACGAGGCTAAGCAGAAAGTAGATGCCTATCATCTGCAGCTCCA GAACCTGTTGTATGAGGTGATGCACCTACAGAAGGAGATCACCAAATGTTTGGAGTTTAA GTCAAAGCATGAAGAAATTGATCTGGTCAGTTTAGAGGAGTTTTATAAGGAGGCTCCACC AGATATCAGCAAGGCCGAAGTCACCATGGGAGACCCTCACCAGCAAACACTGGCACGTCT GGACTGGGAGCTGGAGCAGCGGAAAAGGCTGGCAGAGAAGTACCGAGAGTGCCTATCTAA CAAGGAGAAGATTCTCAAGGAGATTGAGGTGAAGAAGGAGTACCTGAGCAGCCTCCAGCC CCGCCTCAACAGCATCATGCAGGCTTCCCTTCCGGTGCAGGAGTACCTGTTTATGCCATT CGACCAGGCTCACAAGCAGTATGAGACAGCCAGACACCTGCCGCCTCCCCTCTATGTCCT CTTTGTTCAGGCCACTGCGTATGGGCAGGCCTGTGATAAGACGTTATCTGTGGCAATCGA AGGCAGTGTGGATGAAGCCAAGGCTCTGTTCAAACCTCCAGAGGACTCCCAAGATGACGA GAGTGACTCAGATGCCGAGGAGGAGCAGACTACGAAGCGCCGGAGACCCACACTGGGGGT TCAGTTGGACGACAAACGCAAGGAGATGCTGAAGAGGCACCCACTGTCTGTCATGCTCGA CCTGAAGTGCAAAGATGACAGTGTGCTTCACCTGACTTTCTACTACCTCATGAACCTCAA CATCATGACAGTAAAAGCCAAAGTGACAACTGCCATGGAGCTGATCACCCCCATCAGTGC AGGTGACTTGCTGTCTCCTGACTCAGTCCTGAGTTGCTTGTATCCTGGGGATCATGGAAA GAAAACTCCGAATCCAGCCAATCAGTATCAGTTTGATAAAGTTGGCATCCTGACTTTGAG CGACTATGTACTTGAGCTAGGTCACCCCTATTTGTGGGTGCAGAAGCTGGGTGGCCTCCA CTTCCCCAAAGAGCAGCCCCAGCAAACAGTGATTGCTGACCACTCGCTGAGCGCCAGCCA CATGGAGACCACCATGAAACTTCTGAAGACCAGGGTGCAGTCCCGCCTGGCCCTCCACAA ACAGTTTGCATCCCTAGAACATGGCATTGTGCCAGTTACCAGTGATTGCCAGTACCTCTT CCCTGCCAAGGTTGTCTCTCGCCTGGTGAAATGGGTGACAATTGCCCATGAGGATTACAT GGAGCTGCACTTCACCAAAGACATTGTGGATGCGGGACTGGCTGGGGACACCAATCTCTA CTACATGGCGCTCATCGAAAGGGGCACAGCCAAACTGCAGGCCGCTGTGGTGTTGAACCC TGGCTACTCCTCCATCCCACCTATTTTCCAGCTCTGTTTGAACTGGAAAGGGGAGAAAAC CAACAGCAACGATGACAACATTCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGA GCTGTGTGGCCCTTGGCCCAGCCACCAGCTGTTGACCAACCAGCTGCAGCGGCTGTGTGT GCTGCTGGATGTTTACCTGGAGACCGAGAGCCATGACGACAGTGTGGAGGGGCCCAAGGA ATTTCCCCAGGAGAAGATGTGTCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATT TAAATACAACCATCCTCAGGGATTCTTCAGCCATCGCTGATCTCCCGCGCAGACCGTTGT TTCCCCCAAGGCCTCACCCTGAGCACTGGGCTTCTGCTTTCTGCTCTGGCCCACATGTGA CTCTTGATATTCTCCAAAGACACCAGCCAATTAAAAAGCGTCACCTGAAAAAAAAAAAAA AAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_001002878 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001002878.1, NP_001002878.1 |
| RefSeq Size | 2694 bp |
| RefSeq ORF | 2052 bp |
| Locus ID | 8563 |
| UniProt ID | Q13769 |
| Gene Summary | Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC200382 | THOC5 (Myc-DDK-tagged)-Human THO complex 5 (THOC5), transcript variant 1 |
CNY 3,990.00 |
|
| RC200382L3 | Lenti-ORF clone of THOC5 (Myc-DDK-tagged)-Human THO complex 5 (THOC5), transcript variant 1 |
CNY 5,890.00 |
|
| RC200382L4 | Lenti-ORF clone of THOC5 (mGFP-tagged)-Human THO complex 5 (THOC5), transcript variant 1 |
CNY 5,890.00 |
|
| RG200382 | THOC5 (tGFP-tagged) - Human THO complex 5 (THOC5), transcript variant 1 |
CNY 4,370.00 |
|
| SC300471 | THOC5 (untagged)-Human THO complex 5 (THOC5), transcript variant 1 |
CNY 7,220.00 |
