BMI1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 200-1000 WB positive control: 231 and A549 cells, hela cells and mouse brain tissue
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein of human BMI1
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	37 kDa
Gene Name	BMI1 proto-oncogene, polycomb ring finger
Database Link	NP_005171 Entrez Gene 12151 MouseEntrez Gene 648 Human UniProt ID P35226
Background	BMI1 polycomb ring finger oncogene, also known as BMI1, is a protein which in humans is encoded by the BMI1gene. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
Synonyms	BMI1; FLVI2; PCGF4; RNF51
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors

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