Sodium Iodide Symporter (SLC5A5) (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC
Recommend Dilution	Immunofluorescence. Immunohistochemistry on Frozen Sections. Working Dilution: 1/1200-1/2000 using FITC conjugated secondaries. Incubation Time: Overnight at 2-8°C. Positive Control: Frozen sections of Rat thyroid. Suitable for studying the sensitivity of thyroid tumors to iodine treatment.
Reactivity	Human, Porcine, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide from the C-terminus of Rat NIS
Specificity	This antibody recognizes the Na+/I- Symporter. Absorption with 50-100 µg immunogen per ml diluted antiserum abolishes staining.
Formulation	State: Serum State: Lyophilized Serum
Reconstitution Method	Restore in 100 µl distilled water
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store at 2-8°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	solute carrier family 5 member 5
Database Link	Entrez Gene 6528 Human UniProt ID Q92911
Background	Human Sodium Iodide Symporter (hNIS) is responsible for iodide concentrating ability within thyroid follicular cells. It is a membrane bound glycoprotein with 13 membrane spanning domains and 14 extramembranous domains. It may represent an autoantigen in thyroid. Located in the cell membrane of thyroid cells, NIS can allow Sodium and Iodine flow across the membrane.
Synonyms	Sodium-iodide cotransporter, Na+ / I- Symporter, NIS
Reference Data

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