Pdgfb Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Protein Source	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) S82-T190
Tag	N-6His
Buffer	Supplied as a 0.2 um filtered solution of PBS, um Urea pH 7.4
Note	Recombinant Mouse PDGF-B is produced by E.coli. The target gene encoding S82-T190 is expressed with a 6His tag at the N-terminus.
Storage	Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
Stability	12 months from date of despatch
Reference Data
Locus ID	18591
UniProt ID	P31240
Summary	Platelet-derived growth factor beta (PDGFB) is a member of PDGF family. PDGFB can form disulfide-linked homodimer or heterodimer with PDGFA. PDGF proteins mediate diverse cellular functions by binding to and inducing the homo- or hetero-dimerization of two receptors (PDGF R alpha and R beta). PDGFB is essential for cardiovascular development. The administration of PDGFB normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. This effect exerted by PDGFB was also observed in the presence of DAPT. Therefore, PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor.

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