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IGF1 Receptor (IGF1R) (NM_000875) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC214928L1V
- LentiORF®
-
Lenti ORF particles, IGF1R (Myc-DDK tagged) - Human insulin-like growth factor 1 receptor (IGF1R), 200ul, >10^7 TU/mL
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CNY 11,210.00
| Cited in 2 publications. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Product Name | IGF1 Receptor (IGF1R) (NM_000875) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | CD221; IGFIR; IGFR; JTK13 |
| Vector | pLenti-C-Myc-DDK |
| ACCN | NM_000875 |
| ORF Size | 4101 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC214928).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_000875.2 |
| RefSeq Size | 4989 bp |
| RefSeq ORF | 4104 bp |
| Locus ID | 3480 |
| Protein Families | Druggable Genome, Protein Kinase, Transmembrane |
| Protein Pathways | Adherens junction, Colorectal cancer, Endocytosis, Focal adhesion, Glioma, Long-term depression, Melanoma, Oocyte meiosis, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer |
| MW | 154.79 kDa |
| Gene Summary | This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014] |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α1-adrenergic receptors
,null,
Biochemical Journal
,PubMed ID 34002209
[IGF1R]
|
|
miR-140 Suppresses Tumor Growth and Metastasis of Non-Small Cell Lung Cancer by Targeting Insulin-Like Growth Factor 1 Receptor
,null,
PLoS ONE
,PubMed ID 24039995
[IGF1R]
|
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