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APEX2 (NM_014481) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC200320L3V
- LentiORF®
-
Lenti ORF particles, APEX2 (Myc-DDK tagged) - Human APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (APEX2), nuclear gene encoding mitochondrial protein, 200ul, >10^7 TU/mL
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CNY 8,930.00
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Specifications
| Product Data | |
| Product Name | APEX2 (NM_014481) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | APE2; APEXL2; XTH2; ZGRF2 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_014481 |
| ORF Size | 1554 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC200320).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_014481.2 |
| RefSeq Size | 2095 bp |
| RefSeq ORF | 1557 bp |
| Locus ID | 27301 |
| Protein Families | Druggable Genome |
| Protein Pathways | Base excision repair |
| MW | 57.4 kDa |
| Gene Summary | Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012] |
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