United States
Germany
Japan
United Kingdom
China
Grin2b (NM_008171) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR227077L3V
- LentiORF®
-
Lenti ORF particles, Grin2b (Myc-DDK-tagged) - Mouse glutamate receptor, ionotropic, NMDA2B (epsilon 2) (Grin2b), 200ul, >10^7 TU/mL
Mouse Protein / Lysate Request
Need custom lentivirus service?
Get a free quote
CNY 20,710.00
货期*
详询
规格
Product images
经常一起买 (2)
Specifications
| Product Data | |
| Product Name | Grin2b (NM_008171) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AW490526; GluN2B; Nmdar2b; NR2B |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_008171 |
| ORF Size | 4446 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR227077).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_008171.3 |
| RefSeq Size | 7515 bp |
| RefSeq ORF | 4449 bp |
| Locus ID | 14812 |
| Gene Summary | Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:1377365, PubMed:26912815). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:1377365). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (PubMed:20141836). Contributes to neural pattern formation in the developing brain (PubMed:8789948). Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (PubMed:8789948).[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
You may also need
Customer
Reviews
Loading...
