Fgfr2 (BC091652) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR210178L3V

  • LentiORF®

Lenti ORF particles, Fgfr2 (Myc-DDK-tagged) - Mouse fibroblast growth factor receptor 2 (cDNA clone MGC:102519 IMAGE:5349249), 200ul, >10^7 TU/mL

ORF Plasmid: DDK tGFP



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CNY 11,875.00


货期*
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规格
    • 200 ul

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Specifications

Product Data
Product Name Fgfr2 (BC091652) Mouse Tagged ORF Clone Lentiviral Particle
Synonyms KGFRTr
Vector pLenti-C-Myc-DDK-P2A-Puro
ACCN BC091652
ORF Size 2121 bp
Sequence Data
The ORF insert of this clone is exactly the same as(MR210178).
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq BC091652
RefSeq Size 4271 bp
RefSeq ORF 2123 bp
Locus ID 14183
Gene Summary Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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