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Ube2v1 (NM_023230) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR200994L4V
- LentiORF®
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Lenti ORF particles, Ube2v1 (GFP-tagged) - Mouse ubiquitin-conjugating enzyme E2 variant 1 (Ube2v1), 200ul, >10^7 TU/mL
Mouse Protein / Lysate Request
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CNY 8,360.00
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Specifications
| Product Data | |
| Product Name | Ube2v1 (NM_023230) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 0610011J09Rik; AI256840; CROC-1; CROC1; D7Bwg1382e; UEV-1 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_023230 |
| ORF Size | 444 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR200994).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_023230.2, NP_075719.1 |
| RefSeq Size | 1950 bp |
| RefSeq ORF | 444 bp |
| Locus ID | 66589 |
| Gene Summary | Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation (By similarity). Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes (By similarity).[UniProtKB/Swiss-Prot Function] |
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