PTPRN (NM_001199764) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC331357 representing NM_001199764. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGTCCCAAGGATTGTCCTGGCACGATGACCTCACCCAGTATGTGATCTCTCAGGAGATGGAGCGCATC CCCAGGCTTCGCCCCCCAGAGCCCCGTCCAAGGGACAGGTCTGGCTTGGCACCCAAGAGACCTGGTCCT GCTGGAGAGCTGCTTTTACAGGACATCCCCACTGGCTCCGCCCCTGCTGCCCAGCATCGGCTTCCACAA CCACCAGTGGGCAAAGGTGGAGCTGGGGCCAGCTCCTCTCTGTCCCCTCTGCAGGCTGAGCTGCTCCCG CCTCTCTTGGAGCACCTGCTGCTGCCCCCACAGCCTCCCCACCCTTCACTGAGTTACGAACCTGCCTTG CTGCAGCCCTACCTGTTCCACCAGTTTGGCTCCCGTGATGGCTCCAGGGTCTCAGAGGGCTCCCCAGGG ATGGTCAGTGTCGGCCCCCTGCCCAAGGCTGAAGCCCCTGCCCTCTTCAGCAGAACTGCCTCCAAGGGC ATATTTGGGGACCACCCTGGCCACTCCTACGGGGACCTTCCAGGGCCTTCACCTGCCCAGCTTTTTCAA GACTCTGGGCTGCTCTATCTGGCCCAGGAGTTGCCAGCACCCAGCAGGGCCAGGGTGCCAAGGCTGCCA GAGCAAGGGAGCAGCAGCCGGGCAGAGGACTCCCCAGAGGGCTATGAGAAGGAAGGACTAGGGGATCGT GGAGAGAAGCCTGCTTCCCCAGCTGTGCAGCCAGATGCGGCTCTGCAGAGGCTGGCCGCTGTGCTGGCG GGCTATGGGGTAGAGCTGCGTCAGCTGACCCCTGAGCAGCTCTCCACACTCCTGACCCTGCTGCAGCTA CTGCCCAAGGGTGCAGGAAGAAATCCGGGAGGGGTTGTAAATGTTGGAGCTGATATCAAGAAAACAATG GAGGGGCCGGTGGAGGGCAGAGACACAGCAGAGCTTCCAGCCCGCACATCCCCCATGCCTGGACACCCC ACTGCCAGCCCTACCTCCAGTGAAGTCCAGCAGGTGCCAAGCCCTGTCTCCTCTGAGCCTCCCAAAGCT GCCAGACCCCCTGTGACACCTGTCCTGCTAGAGAAGAAAAGCCCACTGGGCCAGAGCCAGCCCACGGTG GCAGGACAGCCCTCAGCCCGCCCAGCAGCAGAGGAATATGGCTACATCGTCACTGATCAGAAGCCCCTG AGCCTGGCTGCAGGAGTGAAGCTGCTGGAGATCCTGGCTGAGCATGTGCACATGTCCTCAGGCAGCTTC ATCAACATCAGTGTGGTGGGACCAGCCCTCACCTTCCGCATCCGGCACAATGAGCAGAACCTGTCTTTG GCTGATGTGACCCAACAAGCAGGGCTGGTGAAGTCTGAACTGGAAGCACAGACAGGGCTCCAAATCTTG CAGACAGGAGTGGGACAGAGGGAGGAGGCAGCTGCAGTCCTTCCCCAAACTGCGCACAGCACCTCACCC ATGCGCTCAGTGCTGCTCACTCTGGTGGCCCTGGCAGGTGTGGCTGGGCTGCTGGTGGCTCTGGCTGTG GCTCTGTGTGTGCGGCAGCATGCGCGGCAGCAAGACAAGGAGCGCCTGGCAGCCCTGGGGCCTGAGGGG GCCCATGGTGACACTACCTTTGAGTACCAGGACCTGTGCCGCCAGCACATGGCCACGAAGTCCTTGTTC AACCGGGCAGAGGGTCCACCGGAGCCTTCACGGGTGAGCAGTGTGTCCTCCCAGTTCAGCGACGCAGCC CAGGCCAGCCCCAGCTCCCACAGCAGCACCCCGTCCTGGTGCGAGGAGCCGGCCCAAGCCAACATGGAC ATCTCCACGGGACACATGATTCTGGCATACATGGAGGATCACCTGCGGAACCGGGACCGCCTTGCCAAG GAGTGGCAGGCCCTCTGTGCCTACCAAGCAGAGCCAAACACCTGTGCCACCGCGCAGGGGGAGGGCAAC ATCAAAAAGAACCGGCATCCTGACTTCCTGCCCTATGACCATGCCCGCATAAAACTGAAGGTGGAGAGC AGCCCTTCTCGGAGCGATTACATCAACGCCAGCCCCATTATTGAGCATGACCCTCGGATGCCAGCCTAC ATAGCCACGCAGGGCCCGCTGTCCCATACCATCGCAGACTTCTGGCAGATGGTGTGGGAGAGCGGCTGC ACCGTCATCGTCATGCTGACCCCGCTGGTGGAGGATGGTGTCAAGCAGTGTGACCGCTACTGGCCAGAT GAGGGTGCCTCCCTCTACCACGTATATGAGGTGAACCTGGTGTCGGAGCACATCTGGTGCGAGGACTTT CTGGTGCGGAGCTTCTACCTGAAGAACGTGCAGACCCAGGAGACGCGCACGCTCACGCAGTTCCACTTC CTCAGCTGGCCGGCAGAGGGCACACCGGCCTCCACGCGGCCCCTGCTGGACTTCCGCAGGAAGGTGAAC AAGTGCTACCGGGGCCGCTCCTGCCCCATCATCGTGCACTGCAGTGATGGTGCGGGGAGGACCGGCACC TACATCCTCATCGACATGGTCCTGAACCGCATGGCAAAAGGAGTGAAGGAGATTGACATCGCTGCCACC CTGGAGCATGTCCGTGACCAGCGGCCTGGCCTTGTCCGCTCTAAGGACCAGTTTGAATTTGCCCTGACA GCCGTGGCGGAGGAAGTGAATGCCATCCTCAAGGCCCTGCCCCAGTGA
Restriction Sites	SgfI-MluI
ACCN	NM_001199764
Insert Size	2670 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001199764.1
RefSeq Size	3570 bp
RefSeq ORF	2670 bp
Locus ID	5798
UniProt ID	Q16849
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Type I diabetes mellitus
MW	96.3 kDa
Gene Summary	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010] Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences causes translation initiation at a downstream AUG and results an isoform (3) with a shorter N-terminus, compared to isoform 1.

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