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Metabotropic Glutamate Receptor 1 (GRM1) (NM_001114329) Human Untagged Clone
CAT＃: SC319004
GRM1 (untagged)-Human glutamate receptor, metabotropic 1 (GRM1), transcript variant 2
CNY 17,390.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | GPRC1A; GRM1A; mGlu1; MGLUR1; MGLUR1A; SCAR13 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>SC319004 representing NM_001114329.
Blue=Insert sequence Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGGTCGGGCTCCTTTTGTTTTTTTTCCCAGCGATCTTTTTGGAGGTGTCCCTTCTCCCCAGAAGCCCC GGCAGGAAAGTGTTGCTGGCAGGAGCGTCGTCTCAGCGCTCGGTGGCCAGAATGGACGGAGATGTCATC ATTGGAGCCCTCTTCTCAGTCCATCACCAGCCTCCGGCCGAGAAAGTGCCCGAGAGGAAGTGTGGGGAG ATCAGGGAGCAGTATGGCATCCAGAGGGTGGAGGCCATGTTCCACACGTTGGATAAGATCAACGCGGAC CCGGTCCTCCTGCCCAACATCACCCTGGGCAGTGAGATCCGGGACTCCTGCTGGCACTCTTCCGTGGCT CTGGAACAGAGCATTGAGTTCATTAGGGACTCTCTGATTTCCATTCGAGATGAGAAGGATGGGATCAAC CGGTGTCTGCCTGACGGCCAGTCCCTCCCCCCAGGCAGGACTAAGAAGCCCATTGCGGGAGTGATCGGT CCCGGCTCCAGCTCTGTAGCCATTCAAGTGCAGAACCTGCTCCAGCTCTTCGACATCCCCCAGATCGCT TATTCAGCCACAAGCATCGACCTGAGTGACAAAACTTTGTACAAATACTTCCTGAGGGTTGTCCCTTCT GACACTTTGCAGGCAAGGGCCATGCTTGACATAGTCAAACGTTACAATTGGACCTATGTCTCTGCAGTC CACACGGAAGGGAATTATGGGGAGAGCGGAATGGACGCTTTCAAAGAGCTGGCTGCCCAGGAAGGCCTC TGTATCGCCCATTCTGACAAAATCTACAGCAACGCTGGGGAGAAGAGCTTTGACCGACTCTTGCGCAAA CTCCGAGAGAGGCTTCCCAAGGCTAGAGTGGTGGTCTGCTTCTGTGAAGGCATGACAGTGCGAGGACTC CTGAGCGCCATGCGGCGCCTTGGCGTCGTGGGCGAGTTCTCACTCATTGGAAGTGATGGATGGGCAGAC AGAGATGAAGTCATTGAAGGTTATGAGGTGGAAGCCAACGGGGGAATCACGATAAAGCTGCAGTCTCCA GAGGTCAGGTCATTTGATGATTATTTCCTGAAACTGAGGCTGGACACTAACACGAGGAATCCCTGGTTC CCTGAGTTCTGGCAACATCGGTTCCAGTGCCGCCTTCCAGGACACCTTCTGGAAAATCCCAACTTTAAA CGAATCTGCACAGGCAATGAAAGCTTAGAAGAAAACTATGTCCAGGACAGTAAGATGGGGTTTGTCATC AATGCCATCTATGCCATGGCACATGGGCTGCAGAACATGCACCATGCCCTCTGCCCTGGCCACGTGGGC CTCTGCGATGCCATGAAGCCCATCGACGGCAGCAAGCTGCTGGACTTCCTCATCAAGTCCTCATTCATT GGAGTATCTGGAGAGGAGGTGTGGTTTGATGAGAAAGGAGACGCTCCTGGAAGGTATGATATCATGAAT CTGCAGTACACTGAAGCTAATCGCTATGACTATGTGCACGTTGGAACCTGGCATGAAGGAGTGCTGAAC ATTGATGATTACAAAATCCAGATGAACAAGAGTGGAGTGGTGCGGTCTGTGTGCAGTGAGCCTTGCTTA AAGGGCCAGATTAAGGTTATACGGAAAGGAGAAGTGAGCTGCTGCTGGATTTGCACGGCCTGCAAAGAG AATGAATATGTGCAAGATGAGTTCACCTGCAAAGCTTGTGACTTGGGATGGTGGCCCAATGCAGATCTA ACAGGCTGTGAGCCCATTCCTGTGCGCTATCTTGAGTGGAGCAACATCGAATCCATTATAGCCATCGCC TTTTCATGCCTGGGAATCCTTGTTACCTTGTTTGTCACCCTAATCTTTGTACTGTACCGGGACACACCA GTGGTCAAATCCTCCAGTCGGGAGCTCTGCTACATCATCCTAGCTGGCATCTTCCTTGGTTATGTGTGC CCATTCACTCTCATTGCCAAACCTACTACCACCTCCTGCTACCTCCAGCGCCTCTTGGTTGGCCTCTCC TCTGCGATGTGCTACTCTGCTTTAGTGACTAAAACCAATCGTATTGCACGCATCCTGGCTGGCAGCAAG AAGAAGATCTGCACCCGGAAGCCCAGGTTCATGAGTGCCTGGGCTCAGGTGATCATTGCCTCAATTCTG ATTAGTGTGCAACTAACCCTGGTGGTAACCCTGATCATCATGGAACCCCCTATGCCCATTCTGTCCTAC CCAAGTATCAAGGAAGTCTACCTTATCTGCAATACCAGCAACCTGGGTGTGGTGGCCCCTTTGGGCTAC AATGGACTCCTCATCATGAGCTGTACCTACTATGCCTTCAAGACCCGCAACGTGCCCGCCAACTTCAAC GAGGCCAAATATATCGCGTTCACCATGTACACCACCTGTATCATCTGGCTAGCTTTTGTGCCCATTTAC TTTGGGAGCAACTACAAGATCATCACAACTTGCTTTGCAGTGAGTCTCAGTGTAACAGTGGCTCTGGGG TGCATGTTCACTCCCAAGATGTACATCATTATTGCCAAGCCTGAGAGGAATGTCCGCAGTGCCTTCACC ACCTCTGATGTTGTCCGCATGCATGTTGGCGATGGCAAGCTGCCCTGCCGCTCCAACACTTTCCTCAAC ATCTTCCGAAGAAAGAAGGCAGGGGCAGGGAATGCCAAGAAGAGGCAGCCAGAATTCTCGCCCACCAGC CAATGTCCGTCGGCACATGTGCAGCTTTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGAT TACAAGGATGACGACGATAAGGTTTAAACGGCCGGC |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_001114329 |
| Insert Size | 2721 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001114329.1 |
| RefSeq Size | 6939 bp |
| RefSeq ORF | 2721 bp |
| Locus ID | 2911 |
| Protein Families | Druggable Genome, GPCR, Transmembrane |
| Protein Pathways | Calcium signaling pathway, Gap junction, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction |
| MW | 101.3 kDa |
| Gene Summary | This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013] Transcript Variant: This variant (2) encodes the shorter isoform (beta). Isoform beta has a different subcellular distribution than isoform alpha and may be functionally distinct due to differential G-protein coupling of its novel C-terminal sequence. |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC226254 | GRM1 (Myc-DDK-tagged)-Human glutamate receptor, metabotropic 1 (GRM1), transcript variant 2 |
CNY 9,952.00 |
|
| RC226254L1 | Lenti ORF clone of Human glutamate receptor, metabotropic 1 (GRM1), transcript variant 2, Myc-DDK-tagged |
CNY 12,352.00 |
|
| RC226254L2 | Lenti ORF clone of Human glutamate receptor, metabotropic 1 (GRM1), transcript variant 2, mGFP tagged |
CNY 12,230.00 |
|
| RC226254L3 | Lenti ORF clone of Human glutamate receptor, metabotropic 1 (GRM1), transcript variant 2, Myc-DDK-tagged |
CNY 12,230.00 |
|
| RC226254L4 | Lenti ORF clone of Human glutamate receptor, metabotropic 1 (GRM1), transcript variant 2, mGFP tagged |
CNY 12,230.00 |
|
| RG226254 | GRM1 (tGFP-tagged) - Human glutamate receptor, metabotropic 1 (GRM1), transcript variant 2 |
CNY 11,400.00 |
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