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p57 Kip2 (CDKN1C) (NM_000076) Human Untagged Clone
CAT＃: SC127869
CDKN1C (untagged)-Human cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant 1
CNY 3,600.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | BWCR; BWS; KIP2; p57; p57Kip2; WBS |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_000076, the custom clone sequence may differ by one or more nucleotides
ATGTCCGACGCGTCCCTCCGCAGCACATCCACGATGGAGCGTCTTGTCGCCCGTGGGACCTTCCCAGTAC TAGTGCGCACCAGCGCCTGCCGCAGCCTCTTCGGGCCGGTGGACCACGAGGAGCTGAGCCGCGAGCTGCA GGCCCGCCTGGCCGAGCTGAACGCCGAGGACCAGAACCGCTGGGATTACGACTTCCAGCAGGACATGCCG CTGCGGGGCCCTGGACGCCTGCAGTGGACCGAAGTGGACAGCGACTCGGTGCCCGCGTTCTACCGCGAGA CGGTGCAGGTGGGGCGCTGCCGCCTGCTGCTGGCGCCGCGGCCCGTCGCGGTCGCGGTGGCTGTCAGCCC GCCCCTCGAGCCGGCCGCTGAGTCCCTCGACGGCCTCGAGGAGGCGCCGGAGCAGCTGCCTAGTGTCCCG GTCCCGGCCCCGGCGTCCACCCCGCCCCCAGTCCCGGTCCTGGCTCCAGCCCCGGCCCCGGCTCCGGCTC CGGTCGCGGCTCCGGTCGCGGCTCCGGTCGCGGTCGCGGTCCTGGCCCCGGCCCCGGCCCCGGCTCCGGC TCCGGCTCCGGCCCCGGCTCCAGTCGCGGCCCCGGCCCCAGCCCCGGCCCCGGCCCCGGCCCCGGCCCCC GCCCCGGCCCCGGCCCCGGACGCGGCGCCTCAAGAGAGCGCCGAGCAGGGCGCGAACCAGGGGCAGCGCG GCCAGGAGCCTCTCGCTGACCAGCTGCACTCGGGGATTTCGGGACGTCCCGCGGCCGGCACCGCGGCCGC CAGCGCCAACGGCGCGGCGATCAAGAAGCTGTCCGGGCCTCTGATCTCCGATTTCTTCGCCAAGCGCAAG AGATCAGCGCCTGAGAAGTCGTCGGGCGATGTCCCCGCGCCGTGTCCCTCTCCAAGCGCCGCCCCTGGCG TGGGCTCGGTGGAGCAGACCCCGCGCAAGAGGCTGCGGTGA >OriGene 5' read for NM_000076 unedited
CCCCCGTCGGATTTTGTATACGACTTCACTATAGGCGGCCGCGCATTCGGCACGAGCTCG AGGGTGCCGGCCAGGCCTGAGCGAGCGAGCTAGCCAGCAGGCATCGAGGGGGCGCGGCTG CCGTCCGGACGAGACAGGCGAACCCGACGCAGAAGAGTCCACCACCGGACAGCCAGGTAG CCGCCGCGTCCCTCGCACACGCAGAGTCGGGCGGCGCGGGGTCTCCCTTGCGCCCGGCCT CCGCCCTCTCCTCCTCTCCTTTCCCCTTCTTCTCGCTGTCCTCTCCTCTCTCGCTGCCCG CGTTTGCGCAGCCCCGGGCCATGTCCGACGCGTCCCTCCGCAGCACATCCACGATGGAGC GTCTTGTCGCCCGTGGGACCTTCCCAGTACTAGTGCGCACCAGCGCCTGCCGCAGCCTCT TCGGGCCGGTGGACCACGAGGAGCTGAGCCGCGAGCTGCAGGCCCGCCTGGTCGAGCTGA ACGCCGAGGACCCGAACCGCTGGGATTACGACTTCCAGCAGGAAATGCCGCTGCGGGGCC CTGGACGCCTGCAGTGGACCGAAATGGACAGCGACTCGGTGCCTGCGGTCTACCCCGAGA CCGTGCAAGTGGGGCGCTGCCGCCCTCCGCTAATGCCCCCCCCCTTCTCGTTCTTGGGGG CTCCCCCCCCGCTCCTTGATCCCGCCCCTGAATGCTTTGACCGCCTTTTGGAGGCGCCCG GAGCATCTGCCCAATGTTCCTTGTTCTGGCACTGCCTCCACACTGGCCGTGATCACGGGT GTGCCTAATTTAAGGGCACGGTCCGGTCCGGACGCGGCGCCGGCGCCGCCCAAGAATTGT ATACGGGACCGGGTCAGGCTGCTCAACCGGATCATCCCTATTATGCGACCCG >OriGene 3' read for NM_000076 unedited
GCACTGNNNATTCCCGGCCAGGAGTGGCACTGGGGAGGGGTCACAGGGATGCCACCCGGG ATCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTT TTTTTGCACTGAGTTTCAGCAGAGATTAAACATTTTATATAAATGACTCTTAAAGCTTTA CACCTTGGGACCAGTGTACCTTCTCGTGCAGAATACATTTAGATATAAAAAGACGTTATT AATACATTGCACAGTTTTCAAAATTTAAAAACAAAACCGAACGCTGCTCTGCGGCAGCCG CCGCCGGTTGCTGCTACATGAACGGTCCCAGCCGAGGCCCAGCGCCCTTCCAACGTCCGC TGCCCCGGCAGGTTCCCTCGGGGCTCTTTGGGCTCTAAATTGGCTCACCGCAGCCTCTTG CGCGGGGTCTGCTCCACCGAGCCCACGCCAGGGGCGGCGCTTGGAGAGGGACACGGCGCG GGGACATCGCCCGACGACTTCTCAGGCGCTGATCTCTTGCGCTTGGCGAAGAAATCGGAG ATCAGAGGCCCGGACAGCTTCTTGATCGCCGCGCCGTTGGCGCTGGCGGCCGCGGTGCCG GCCGCGGGACGTCCCGAAATCCCCGAGTGCAGCTGGTCAACGAGAGGCTCCTGGCCGCGC TGCCCCTGGTTCGCGCCCTGGTCGGCGCTCTTTTTGAGCGCCGCGTCCGGGGCCG |
| Restriction Sites | Please inquire |
| ACCN | NM_000076 |
| Insert Size | 1700 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_000076.1, NP_000067.1 |
| RefSeq Size | 1511 bp |
| RefSeq ORF | 951 bp |
| Locus ID | 1028 |
| UniProt ID | P49918 |
| Domains | CDI |
| Protein Families | Druggable Genome |
| Protein Pathways | Cell cycle |
| Gene Summary | This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010] Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1 and 3 both encode isoform a. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
CDKN1C Negatively Regulates RNA Polymerase II C-terminal Domain Phosphorylation in an E2F1-dependent Manner
,Yihong Ma, Lu Chen, Gabriela M. Wright, Smitha R. Pillai, Srikumar P. Chellappan, and W. Douglas Cress,
J. Biol. Chem., Mar 2010; 285: 9813 - 9822
[CDKN1C]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC209840 | CDKN1C (Myc-DDK-tagged)-Human cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant 1 |
CNY 3,600.00 |
|
| RC209840L1 | Lenti-ORF clone of CDKN1C (Myc-DDK-tagged)-Human cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant 1 |
CNY 6,000.00 |
|
| RC209840L2 | Lenti-ORF clone of CDKN1C (mGFP-tagged)-Human cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant 1 |
CNY 5,890.00 |
|
| RC209840L3 | Lenti-ORF clone of CDKN1C (Myc-DDK-tagged)-Human cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant 1 |
CNY 5,890.00 |
|
| RC209840L4 | Lenti-ORF clone of CDKN1C (mGFP-tagged)-Human cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant 1 |
CNY 5,890.00 |
|
| RG209840 | CDKN1C (tGFP-tagged) - Human cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant 1 |
CNY 5,200.00 |
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