QDPR (BC000576) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	DHPR; PKU2; SDR33C1
Vector	pCMV6-XL5
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >OriGene sequence for BC000576 edited GGGAGCCGGGCTGGCAGGAGCAGGATGGCGGCGGCGGCGGCTGCAGGCGAGGCGCGCCGG GTGCTGGTGTACGGCGGCAGGGGCGCTCTGGGTTCTCGATGCGTGCAGGCTTTTCGGGCC CGCAACTGGTGGGTTGCCAGCGTTGATGTGGTGGAGAATGAAGAGGCCAGCGCTAGCATC ATTGTTAAAATGACAGACTCGTTCACTGAGCAGGCTGACCAGGTGACTGCTGAGGTTGGA AAGCTCTTGGGTGAAGAGAAGGTGGATGCAATTCTTTGCGTTGCTGGAGGATGGGCCGGG GGCAATGCCAAATCCAAGTCTCTCTTTAAGAACTGTGACCTGATGTGGAAGCAGAGCATA TGGACATCGACCATCTCCAGCCATCTGGCTACCAAGCATCTCAAGGAAGGAGGCCTCCTG ACCTTGGCTGGCGCAAAGGCTGCCCTGGATGGGACTCCTGGTATGATCGGGTACGGCATG GCCAAGGGTGCTGTTCACCAGCTCTGCCAGAGCCTGGCTGGGAAGAACAGCGGCATGCCG CCCGGGGCAGCCGCCATCGCTGTGCTCCCGGTTACCCTGGATACCCCGATGAACAGGAAA TCAATGCCTGAGGCTGACTTCAGCTCCTGGACACCCTTAGAATTCCTAGTTGAAACTTTC CATGACTGGATCACAGGGAAAAACCGACCGAGCTCAGGAAGCCTAATCCAGGTGGTAACC ACAGAAGGAAGGACGGAACTCACCCCAGCATATTTTTAGGCCTCATCTCAGTGCCTATGA GGGGCCTGCCAGAAAAGTCACTAACCTGTCTCAGTGTGGCCTTGTCCAGCCTTGTGTTTT CTGTAACCCCTGTTTGTGGTACGAGATAATGAGTCCTATTTTTCTCTCACATAATATGCA TTTGCTCTCCTAGGACAGTGTAATACATTTATGTGAAGTAAAGACATGCGAGACTGGTGG CCTGCAAATAGCATCCGTCAATCTGTGTTAACTGCATAGGGAGGGCTCTGCATAGCACCT GCTATAGCGGTGTCATGTTGGATCGCTTTTGTGACTGTTCATCTGTCCTTGACAGTGGCT GTCATCTTGACTACTTTGTTGATTTGTTGGTATTGGGGACATTTTAAAGGCTGAGTTATT TTTGAATGTCATGTTTATGTCATAGACGTAGTTTTCGCATCCTTGAATTAAACTGCCTTA ACTCCTTTTGTGGTATAAGCAAAACTCCATGGACTCTGTCCTGGTATCCTTTTCCTGTGT GGTTGCCCTGTGTCCTCTGGCCTAGGGTTAAGTGTGCAAGATAACTACTCGTGAGTATTC AGAATGTTGTTCCTAATAAATGCACTTGTTGTCTGTCTTCTTTAAAAAAAAAAAAAAAAA AAAAA 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for BC000576 unedited NGTACAGTACAAAATTTGTATACGACTCACTATAGGCGGCCGCGNAATTCGCACGAGGGG AGCCGGGCTGGCAGGAGCAGGATGGCGGCGGCGGCGGCTGCAGGCGAGGCGCGCCGGGTG CTGGTGTACGGCGGCAGGGGCGCTCTGGGTTCTCGATGCGTGCAGGCTTTTCGGGCCCGC AACTGGTGGGTTGCCAGCGTTGATGTGGTGGAGAATGAAGAGGCCAGCGCTAGCATCATT GTTAAAATGACAGACTCGTTCACTGAGCAGGCTGACCAGGTGACTGCTGAGGTTGGAAAG CTCTTGGGTGAAGAGAAGGTGGATGCAATTCTTTGCGTTGCTGGAGGATGGGCCGGGGGC AATGCCAAATCCAAGTCTCTCTTTAAGAACTGTGACCTGATGTGGAAGCAGAGCATATGG ACATCGACCATCTCCAGCCATCTGGCTACCAAGCATCTCAAGGAAGGAGGCCTCCTGACC TTGGCTGGCGCAAAGGCTGCCCTGGATGGGACTCCTGGTATGATCGGGTACGGCATGGCC AAGGGTGCTGTTCACCAGCTCTGCCAGAGCCTGGCTGGGAAGAACAGCGGCATGCCGCCC GGGGCAGCCGCCATCGCTGTGCTCCCGGTTACCCTGGATACCCCGATGAACAGGAAATCA ATGCCTGAGGCTGACTTCAGCTCCTGGACACCCTTAGAATTCCTAGTTGAAACTTTCCAT GACTGGATCACAGGGAAAAACCGACCGAGCTCAGGAAGCCTAATCCAGGTGGTAACCCAC AGAGGAAGGACCGAACTCACCCCAGCATATTTTTAGGCCTCATCTCATTGCCTATGAAGG GCCTGNCCAAAAAGTCACTTACCTGTCTCAGTGTGGCCTTGTCCAGCCCTGGTGTTTCTG TAACC
Restriction Sites	Please inquire
ACCN	BC000576
Insert Size	1394 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	BC000576.2, AAH00576.1
RefSeq Size	1385 bp
Locus ID	5860
Protein Families	Druggable Genome
Protein Pathways	Folate biosynthesis, Metabolic pathways
Gene Summary	This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature terminations. Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase. [provided by RefSeq, Jul 2008]

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