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emopamil binding protein (EBP) (NM_006579) Human Untagged Clone
CAT＃: SC116006
EBP (untagged)-Human emopamil binding protein (sterol isomerase) (EBP)
CNY 2,400.00
CNY 2,950.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CDPX2; CHO2; CPX; CPXD; MEND |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC116006 sequence for NM_006579 edited (data generated by NextGen Sequencing)
ATGACTACCAACGCGGGCCCCTTGCACCCATACTGGCCTCAGCACCTAAGACTGGACAAC TTTGTACCTAATGACCGCCCCACCTGGCATATACTGGCTGGCCTCTTCTCTGTCACAGGG GTCTTAGTCGTGACCACATGGCTGTTGTCAGGTCGTGCTGCGGTTGTCCCATTGGGGACT TGGCGGCGACTGTCCCTGTGCTGGTTTGCAGTGTGTGGGTTCATTCACCTGGTGATCGAG GGCTGGTTCGTTCTCTACTACGAAGACCTGCTTGGAGACCAAGCCTTCTTATCTCAACTC TGGAAAGAGTATGCCAAGGGAGACAGCCGATACATCCTGGGTGACAACTTCACAGTGTGC ATGGAAACCATCACAGCTTGCCTGTGGGGACCACTCAGCCTGTGGGTGGTGATCGCCTTT CTCCGCCAGCATCCCCTCCGCTTCATTCTACAGCTTGTGGTCTCTGTGGGCCAGATCTAT GGGGATGTGCTCTACTTCCTGACAGAGCACCGCGACGGATTCCAGCACGGAGAGCTGGGC CACCCTCTCTACTTCTGGTTTTACTTTGTCTTCATGAATGCCCTGTGGCTGGTGCTGCCT GGAGTCCTTGTGCTTGATGCTGTGAAGCACCTCACTCATGCCCAGAGCACGCTGGATGCC AAGGCCACAAAAGCCAAGAGCAAGAAGAACTGA Clone variation with respect to NM_006579.2 >OriGene 5' read for NM_006579 unedited
AGGAATTTGTAAACGACTCACTATAGGCGGCCCGCGAATCGGCACGAGGCCTCGTGCCGA ATTCGGCACGAGGGACCGGCTTTGTGTTCCGTTCTAGCGCTGCACGCCAGACACCGGCCT TTCAATATCCGTCTCTTCCCTGCAGGTTGACGGCGTTGCACGCTCTCGCGGGGAGGCTCT GGCTTTCCAAACGCTGGCACCGAGGGTTNTTCTGTTCCTTTTTTTTTTTTTTTTTTAACT TCCTGCCTATACACACGCAGCCATCAGCCCACAAAGACATGACTACCAACGCGGGCCCCT TGCACCCATACTGGCCTCAGCACCTAAGACTGGACAACTTTGTACCTAATGACCGCCCCA CCTGGCATATACTGGCTGGCCTCTTCTCTGTCACAGGGGTCTTAGTCGTGACCACATGGC TGTTGTCAGGTCGTGCTGCGGTTGTCCCATTGGGGACTTGGCGGCGACTGTCCCTGTGCT GGTTTGCAGTGTGTGGGTTCATTCACCTGGTGATCGAGGGCTGGTTCGTTCTCTACTACG AAGACCTGCTTGGAGACCAAGCCTTCTTATCTCAACTCTGGAAAGAGTATGCCAAGGGAG ACAGCCGATACATCCTGGGTGACAACTTCACAGTGTGCATGGAAACCATCACAGCTTGCC TGTGGGGACCACTCAGCCTGTGGGTGGTGATCGCCTTTCTCCGCCAGCATCCCCTCCGCT TTATTCTACAGCTTGTGGTCTCTGTGGGCCAGATCTATGGGGGATGTGCTCTACTTCCTG ACAGACACCGCGACGGATCCCGCACGGAGAGCTGGGCCCCCCTCCTACTTCGGGTTTACT TTGCCTCATGAAGCCCTGGGGCTGAGCTGCCTGAAACCCCTGGCTTGAGCT >OriGene 3' read for NM_006579 unedited
TGTAACGAGGCTCGCATTTTAGNATCGAGCCCTCCCCCCCTCCTTTTTTTTTTTTTTTTT TTTTTTTTTTTTTTTTTTTTTAAAGGCAAAATCTTTTATTTCCTGATTTTAAAAATCGTC ACCATCATAAACCTCCTGGCCTTTCTTGCACCCGGGTTCTAATGGCTCCCAACAGGGCCT TCACACAGCCCTTTTATTCCCCTTTTTGGGCCTGCCAATGACCCTGACGGTGAACCACCA AACAGCTTCGCCCCTCCAAACTGGGGGAGCCCGACCACCATTTTTTGGCAGGCAAATAGC TTTTCCTGGGCCAGGGTTCCACCCTGGTCCACCATTCCCAAACCCTTTTTGCCCCGGGCT TCCGGGGCCTTGGCATCCAACGGGCTTTGGGCATGAGGGAGGCTTTTCCTATTATCAAGT ATAAGGACTTCAGGGAGAACCACCCCCAGGGCCCTTCTTACCACCCCCTTTTACCCCCCG TTCCGAGGGGGGCCACACTTCCCGCGCTGGAATCCCCCGCGGGGCTCTGGCTGCAATTCA AACCCCTCCCCTTACCACCCGCCCCCCCAGAACCATAATCTCACAAAGAATCTTCCGCCA TCTTCGCCCCCACAAGGTCCCCTCCACCCCACAGGCGACGGTTCCTTCCCAGTTTTTTTT CTTGGTTTCCCCGCCCATTTGTTCCCGTTTTCCCCAGCACGGATGCGCCGTCCCCCTGCA ATACCTTTTGAAGATTCTTATACCCCCCTTGTTTTCCACCCCCCTCCCCCGCACCCAAGA ACCATCTTTTCATCCAGTGCATGAAACCAAATTTTGGAAACACCCCCGCCCCGCCCGCGC CATCCCCCCCGGCAACGCCCAAATTTTTGTCCCCCCCTGTTGTCACTATTAACCCCCTTG CCACAAAAAACGCTTCCCTATTTTTCCGGCCGCCGGTCCTCCGTCCATATATTTCTCCTT CACCCCGCCGCCCACCGCG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_006579 |
| Insert Size | 1250 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_006579.1, NP_006570.1 |
| RefSeq Size | 1073 bp |
| RefSeq ORF | 693 bp |
| Locus ID | 10682 |
| UniProt ID | Q15125 |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Metabolic pathways, Steroid biosynthesis |
| Gene Summary | The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome). [provided by RefSeq, Jul 2008] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor
,null,
Proceedings of the National Academy of Sciences of the United States of America
,PubMed ID 29078321
[EBP]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC201706 | EBP (Myc-DDK-tagged)-Human emopamil binding protein (sterol isomerase) (EBP) |
CNY 2,400.00 |
|
| RC201706L1 | Lenti ORF clone of Human emopamil binding protein (sterol isomerase) (EBP), Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC201706L2 | Lenti ORF clone of Human emopamil binding protein (sterol isomerase) (EBP), mGFP tagged |
CNY 5,890.00 |
|
| RC201706L3 | Lenti ORF clone of Human emopamil binding protein (sterol isomerase) (EBP), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC201706L4 | Lenti ORF clone of Human emopamil binding protein (sterol isomerase) (EBP), mGFP tagged |
CNY 5,890.00 |
|
| RG201706 | EBP (tGFP-tagged) - Human emopamil binding protein (sterol isomerase) (EBP) |
CNY 4,000.00 |
|
| SC322500 | EBP (untagged)-Human emopamil binding protein (sterol isomerase) (EBP) |
CNY 2,400.00 |
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