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MARK1 (NM_018650) Human Untagged Clone
CAT＃: SC113408
MARK1 (untagged)-Human MAP/microtubule affinity-regulating kinase 1 (MARK1)
CNY 5,560.00
CNY 7,220.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | MARK; Par-1c; Par1c |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_018650 edited
ATGTCGGCCCGGACGCCATTGCCGACGGTGAACGAGCGGGACACGGAAAATCATACATCT GTGGATGGATATACTGAACCACACATCCAGCCTACCAAGTCGAGTAGCAGACAGAACATC CCCCGGTGTAGAAACTCCATTACGTCAGCAACAGATGAACAGCCTCACATTGGAAATTAC CGTTTACAAAAAACAATAGGGAAGGGAAATTTTGCCAAAGTCAAATTGGCAAGACACGTT CTAACTGGTAGAGAGGTTGCTGTGAAAATAATAGACAAAACTCAGCTAAATCCTACCAGT CTACAAAAGAAATATATCTACCTGTTTTCTTTAACAGTTATTTCGAGAAGTACGAATAAT GAAGATACTGAATCATCCTAATATAGTAAAATTGTTTGAAGTTATTGAAACAGAGAAGAC TCTCTATTTAGTCATGGAATACGCGAGTGGGGGTGAAGTATTTGATTACTTAGTTGCCCA TGGAAGAATGAAAGAGAAAGAGGCCCGTGCAAAATTTAGGCAGATTGTATCTGCTGTACA GTATTGTCATCAAAAGTACATTGTTCACCGTGATCTTAAGGCTGAAAACCTTCTCCTTGA TGGTGATATGAATATTAAAATTGCTGACTTTGGTTTTAGTAATGAATTTACAGTTGGGAA CAAATTGGACACATTTTGTGGAAGCCCACCCTATGCTGCTCCCGAGCTTTTCCAAGGAAA GAAGTATGATGGGCCTGAAGTGGATGTGTGGAGTCTGGGCGTCATTCTCTATACATTAGT CAGTGGCTCCTTGCCTTTCGATGGCCAGAATTTAAAGGAACTGCGAGAGCGAGTTTTACG AGGGAAGTACCGTATTCCCTTCTATATGTCCACAGACTGTGAAAATCTTCTGAAGAAATT ATTAGTCCTGAATCCAATAAAGAGAGGCAGCTTGGAACAAATAATGAAAGATCGATGGAT GAATGTTGGTCATGAAGAGGAAGAACTAAAGCCATATACTGAGCCTGATCCGGATTTCAA TGACACAAAAAGAATAGACATTATGGTCACCATGGGCTTTGCACGAGATGAAATAAATGA TGCCTTAATAAATCAGAAGTATGATGAAGTTATGGCTACTTATATTCTTCTAGGTAGAAA ACCACCTGAATTTGAAGGTGGTGAATCGTTATCCAGTGGAAACTTGTGTCAGAGGTCCCG GCCCAGTAGTGACTTAAACAACAGCACTCTTCAGTCCCCTGCTCACCTGAAGGTCCAGAG AAGTATCTCAGCAAATCAGAAGCAGCGGCGTTTCAGTGATCATGCTGGTCCATCCATTCC TCCTGCTGTATCATATACCAAAAGACCTCAGGCTAACAGTGTGGAAAGTGAACAGAAAGA GGAGTGGGACAAAGATGTGGCTCGAAAACTTGGCAGCACAACAGTTGGATCAAAAAGCGA GATGACTGCAAGCCCTCTTGTAGGGCCAGAGAGGAAAAAATCTTCAACTATTCCAAGTAA CAATGTGTATTCTGGAGGTAGCATGGCAAGAAGGAATACATATGTCTGTGAAAGGACCAC AGATCGATACGTAGCATTGCAGAATGGAAAAGACAGCAGCCTTACGGAGATGTCTGTGAG TAGCATATCTTCTGCAGGCTCTTCTGTGGCCTCTGCTGTCCCCTCAGCACGACCCCGCCA CCAGAAGTCCATGTCCACTTCTGGTCATCCTATTAAAGTCACACTGCCAACCATTAAAGA CGGCTCTGAAGCTTACCGGCCTGGTACAACCCAGAGAGTGCCTGCTGCTTCCCCATCTGC TCACAGTATTAGTACTGCGACTCCAGACCGGACCCGTTTTCCCCGAGGGAGCTCAAGCCG AAGCACTTTCCATGGTGAACAGCTCCGGGAGCGACGCAGCGTTGCTTATAATGGGCCACC TGCTTCACCATCCCATGAAACGGGTGCATTTGCACATGCCAGAAGGGGAACGTCAACTGG TATAATAAGCAAAATCACATCCAAATTTGTTCGCAGGGATCCAAGTGAAGGCGAAGCCAG TGGCAGAACCGACACCTCAAGAAGTACATCAGGGGAACCAAAAGAAAGAGACAAGGAAGA GGGTAAAGATTCTAAGCCGCGTTCTTTGCGGTTCACATGGAGTATGAAGACCACTAGTTC AATGGACCCTAATGACATGATGAGAGAAATCCGAAAAGTGTTAGATGCAAATAACTGTGA TTATGAGCAAAAAGAGAGATTTTTGCTTTTCTGTGTCCATGGAGACGCTAGACAGGATAG CCTCGTGCAGTGGGAGATGGAAGTCTGCAAGTTGCCACGACTGTCACTTAATGGGGTTCG CTTCAAGCGAATATCTGGGACATCTATTGCCTTTAAGAACATTGCATCAAAAATAGCAAA TGAGCTTAAGCTGTAAAGAAGTCCAAATTTACAGGTTCAGGGAAGATACATACATATATG AGGTACAGTTTTTGAATGTACTGGTAATGCCTAATGTGGTCTGCCTGTGAATCTCCCCAT GTAGAATTTGCCCTTAATGCAATAAGGTTATACATAGTTATGAACTGTAAAATTAAAGTC AGTATGAACTATAATAAATATCTGTAGCTTAAAAAGTAGGTTCACATGTACAGGTAAGTA TATTGTGTATTTCTGTTCATTTTCTGTTCATAGAGTTGTATAATAAAACATGATTGCTTA AAAACTTGTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACTCGACTCTAGATTGCGGCC GCGGTCATAGCAGTTTCCTGAACAGATCCCGGGTGGCATCC >OriGene 5' read for NM_018650 unedited
GGTTCAAATATTTGTATACGACTCACTATAGGGGGCGGCCGCGCAATTCGGCACGAGGCA GCGCCGGGCAACCGCCTCGCCCGAAGCCCTCCCTCGTTACTGTCCGCATACCCCGGCGGC GCCGCCGCGGGAAGCGGCTCCCCCTCCTCTTCCTCCGCGTCCTCTTCCCTCTTTCCCCCG CCGGGGCCGCTTGTTGCACCGCCCCGCGGCCTGCGGGAGCCGCTCGCCCCGGCCTTGTGC TCGCGTCCGCACCCCTTTCCTGTCGCCCCCCGGGGCCCGCACCACAGCCCGGCCGGCGAG ACCCCGGCCAGACCCCGCTGCCCGCACAAAATGTCGGCCCGGACGCCATTGCCGACGGTG AACGAGCGGGACACGGAAAATCATACATCTGTGGATGGATATACTGAACCACACATCCAG CCTACCAAGTCGCGTAGCAGACAGAACATCCCCCGGTGTAGAAACTCCATTACGTCAGCA ACAGATGAACAGCCTCACATTGGAAATTACCGTTTACAAAAAACAATAGGGAAGGGAAAT TTTGCCAAAGTCAAATTGGCAAGACACGTTCTAACTGGTAGAGAGGTTGCTGTGAAAATA ATAGACCAAACTCAGCTAAATCCTACCAGTCTACANAAGAAATATATCTACCTGTTTTCT TTAACAGTTATTTCGAGAAGTACGAATAATGAAGATACTGAATCATCCTAATATAGTAAA ATTTGTCTGAAGTTATTGAAACAGAGAAGACTCTCTATCTAGTCATGCAATACGCGAGTG GGGGTGAAGTATTTGATTACTTAGTTGCCCATGGAAGATTGAAAGAGAAAGAAGCCCGTG CAAAATTAGGCAGATTTATCTGCTGCCCAGATTGTCATCAAAATACATGGTCACCGTGAT CTTAGGCTGAAACCT >OriGene 3' read for NM_018650 unedited
CGCGGCCGCAATCTANAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTACAAGT TTTTAAGCAATCATGTTTTATTATACAACTCTATGAACAGAAAATGAACAGAAATACACA ATATACTTACCTGTACATGTGAACCTACTTTTTAAGCTACAGATATTTATTATAGTTCAT ACTGACTTTAATTTTACAGTTCATAACTATGTATAACCTTATTGCATTAAGGGCAAATTC TACATGGGGAGATTCACAGGCAGACCACATTAGGCATTACCAGTACATTCAAAAACTGTA CCTCATATATGTATGTATCTTCCCTGAACCTGTAAATTTGGACTTCTTTACAGCTTAAGC TCATTTGCTATTTTTGATGCAATGTTCTTAAAGGCAATAGATGTCCCAGATATTCGCTTG AAGCGAACCCCATTAAGTGACAGTCGTGGCAACTTGCAGACTTCCATCTCCCACTGCACG AGGCTATCCTGTCTAGCGTCTCCATGGACACAGAAAAGCAAAAATCTCTCTTTTTGCTCA TAATCACAGTTATTTGCATCTAACACTTTTCGGATTTCTCTCATCATGTCATTAGGGGCC ATTGAACTAGTGGTCTTCATACTCCATGTGAAACCGCAAGAACGCGGCTTAAAATCTTTA CCCTCTTCCTTGGCTCTTTCTTTGGGNTCCCCTGATGTACTTCTTGGAGGGGTCGGNNTC TGCCACTGGCTTCGCCTTCACTTGGGATCCCTGCGAAAAATTGGGATGTGATTTTGCTTA TATACCAATTGACGGTTCCCTTCTTGGATGTGCAAATGCCACCCGTTCATGGGAGGGGAA ACAGGTGGCCCCTTATAGCCACGCTGGGTCGCTTCGGACCTGTTACATTGAAAGGGCTTC GTTTGACCCCTCGGGAAACGGGTCCGTCTGATTCCAGACTAAACGGGACAAAG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_018650 |
| Insert Size | 3180 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_018650.2, NP_061120.2 |
| RefSeq Size | 4638 bp |
| RefSeq ORF | 2277 bp |
| Locus ID | 4139 |
| UniProt ID | Q9P0L2 |
| Domains | UBA, pkinase, TyrKc, KA1, S_TKc |
| Protein Families | Druggable Genome, Protein Kinase |
| Gene Summary | Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Role of Partitioning-defective 1/Microtubule Affinity-regulating Kinases in the Morphogenetic Activity of Helicobacter pylori CagA
,Huaisheng Lu, Naoko Murata-Kamiya, Yasuhiro Saito, and Masanori Hatakeyama,
J. Biol. Chem., Aug 2009; 284: 23024 - 23036
[MARK1]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC221556 | MARK1 (Myc-DDK-tagged)-Human MAP/microtubule affinity-regulating kinase 1 (MARK1) |
CNY 3,990.00 |
|
| RC221556L1 | Lenti-ORF clone of MARK1 (Myc-DDK-tagged)-Human MAP/microtubule affinity-regulating kinase 1 (MARK1) |
CNY 5,890.00 |
|
| RC221556L2 | Lenti-ORF clone of MARK1 (mGFP-tagged)-Human MAP/microtubule affinity-regulating kinase 1 (MARK1) |
CNY 5,890.00 |
|
| RC221556L3 | Lenti-ORF clone of MARK1 (Myc-DDK-tagged)-Human MAP/microtubule affinity-regulating kinase 1 (MARK1) |
CNY 5,890.00 |
|
| RC221556L4 | Lenti-ORF clone of MARK1 (mGFP-tagged)-Human MAP/microtubule affinity-regulating kinase 1 (MARK1) |
CNY 5,890.00 |
|
| RG221556 | MARK1 (tGFP-tagged) - Human MAP/microtubule affinity-regulating kinase 1 (MARK1) |
CNY 4,370.00 |
|
| SC318279 | MARK1 (untagged)-Human MAP/microtubule affinity-regulating kinase 1 (MARK1) |
CNY 5,832.00 |
|
| SC323553 | MARK1 (untagged)-Kinase deficient mutant (K89M) of Human MAP/microtubule affinity-regulating kinase 1 (MARK1) |
CNY 5,560.00 |
