Cardiac Troponin T (TNNT2) Mouse Monoclonal Antibody [Clone ID: UMAB205]

Specifications

Product Data
Clone Name	UMAB205
Applications	10k-ChIP, IHC, WB
Recommend Dilution	IHC 1:100~200
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human TNNT2 (NP_000355) produced in E.coli.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	35.4 kDa
Gene Name	troponin T2, cardiac type
Database Link	NP_000355 Entrez Gene 21956 MouseEntrez Gene 24837 RatEntrez Gene 7139 Human UniProt ID P45379
Background	The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. (provided by RefSeq, Jul 2008)
Synonyms	CMD1D; CMH2; CMPD2; cTnT; LVNC6; RCM3; TnTC
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)

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