DNA Polymerase lambda (POLL) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000
Reactivity	Human, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to amino acids 448-508 of Human DNA pol λ.
Specificity	DNA pol λ (R478) pAb detects endogenous levels of DNA pol λ protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 64 kDa
Gene Name	polymerase (DNA) lambda
Database Link	Entrez Gene 27343 Human UniProt ID Q9UGP5
Background	DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases. In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches. These exonucleases include the family of DNA polymerases. DNA pol α, β, δ, and ε are involved in DNA replication and repair. DNA pol δ and DNA pol e are multisubunit enzymes, with DNA pol δ consisting of two subunits: p125, which interacts with the sliding DNA clamp protein PCNA; and p50. The nuclear-encoded DNA pol γ is the only DNA polymerase required for the replication of the mitochondrial DNA. DNA pol ζ is ubiquitously expressed in various tissues and mediates the cellular mechanism of damage induced mutagenesis. DNA pol θ is a DNA polymerasehelicase that binds ATP and is involved in the repair of interstrand crosslinks.
Synonyms	DNA polymerase beta-2; DNA polymerase kappa; DNA polymerase lambda; Pol beta2; POLL; Pol Lambda
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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