AMPK beta 1 (PRKAB1) Mouse Monoclonal Antibody [Clone ID: 1A7-E11-E9]

Specifications

Product Data
Clone Name	1A7-E11-E9
Applications	IF, IHC, IP, WB
Recommend Dilution	WB: 1:1000, IF: 1:100
Reactivity	Human, Mouse, Rat, Monkey
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for PRKAB1 antibody: purified recombinant human AMPK beta 1 protein fragments expressed in E.coli.
Formulation	Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	38 kDa
Gene Name	protein kinase AMP-activated non-catalytic subunit beta 1
Database Link	NP_006244 Entrez Gene 19079 MouseEntrez Gene 83803 RatEntrez Gene 695737 MonkeyEntrez Gene 5564 Human UniProt ID Q9Y478
Background	The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK).AMPK is a heterotrimer consisting of an alpha catalytic subunit,and non-catalytic beta and gamma subunits.AMPK is an important energy-sensing enzyme that monitors cellular energy status.In response to cellular metabolic stresses,AMPK is activated,and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR),key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol.This subunit may be a positive regulator of AMPK activity.The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq,Jul 2008]
Synonyms	AMPK; HAMPKb
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Adipocytokine signaling pathway, Hypertrophic cardiomyopathy (HCM), Insulin signaling pathway

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