GLI2 Rabbit Polyclonal Antibody

CAT#: TA336950

Rabbit Polyclonal GLI-2 Antibody



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CNY 5,381.00


货期*
5周

规格
    • 100 ul

Product images

经常一起买 (2)
Transient overexpression lysate of GLI family zinc finger 2 (GLI2)
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Specifications

Product Data
Applications ICC/IF, IHC
Recommend Dilution Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin: 1:200 - 1:300, Immunohistochemistry: 1:200 - 1:300, Immunocytochemistry/ Immunofluorescence: 1:50 - 1:200
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen A synthetic peptide made to an internal portion of the human Gli2 protein (between residues 300-400) [UniProt P10070]
Formulation PBS, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Immunogen affinity purified
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name GLI family zinc finger 2
Background Gli2, also known as THP, is a transcription factor which binds DNA through zinc finger motifs. Belonging to the C2H2-Zinc finger type subclass of the Gli family, Gli2 is a mediator of Shh (sonic hedgehog) signaling, a pathway that is aberrantly activated in many types of cancers. Specifically, it has been found that the anti-apoptotic protein BCL-2 is up regulated by Gli2, leading to carcinogenesis. The protein encoded by the Gli2 gene localizes to the cytoplasm and activates patched (Drosophila homolog) gene expression, where it has been thought to play an important role during embryogenesis. Mutations in the Gli2 gene are found in various syndromes, including Pallister-Hall Syndrome, Greig cephalopolysyndactyly syndrome, and preaxial polydactyl type IV. Recently, the interaction between the hedgehog signaling pathway and Gli2 has been implicated in medullary thyroid carcinoma (PMID: 23410206).
Synonyms CJS; HPE9; PHS2; THP1; THP2
Note In Immunocytochemistry/Immunofluorescence, cytoplasmic and nuclear staining was observed in HeLa cells. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
Reference Data
Protein Families Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS
Protein Pathways Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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