CD31 (PECAM1) Rat Monoclonal Antibody [Clone ID: MEC 7.46]

Specifications

Product Data
Clone Name	MEC 7.46
Applications	FC, ICC/IF, IHC, IP
Recommend Dilution	Immunohistochemistry-Paraffin: 1:10-1:500, Flow (Cell Surface), Immunohistochemistry: 1:100-1:500, Immunocytochemistry/ Immunofluorescence: 1:100-1:500, Immunoprecipitation: 1:10-1:500, Immunohistochemistry-Frozen: 1:100-1:500, Flow Cytometry: 1:10-1:1000, In vivo assay
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	mouse endothelial cell line T-end
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	platelet and endothelial cell adhesion molecule 1
Database Link	NP_000433 Entrez Gene 18613 Mouse UniProt ID P16284
Background	CD31/PECAM1 is commonly used as an endothelial marker, particularly in angiogenesis. CD31/PECAM1 is important in assisting placental and endometrial vascular development. However, CD31/PECAM1 is also associated with many negative angiogenic occurrences, particularly those within or related to tumors and other disease lesions. In MS, plasma microparticules carry CD31/PECAM1 and are important in the formation of brain lesions associated with MS. In cardiac angiosarcoma, CD31/PECAM1 presence is indicative of the severity of the disease. In prostate tumor cells, CD31/PECAM1 is upregulated and associated with increased levels of HIF1a, VEGF, and other hypoxic markers. This relationship seems to indicate that when prostate cancer reaches a sufficient state of development that intense angiogenesis must occur in order to support the ongoing growth and survival of the cancer cells. In all, CD31/PECAM1 is a great marker for normal and disease-induced angiogenesis.
Synonyms	CD31; EndoCAM; endoCAM; GPIIA; PECA1; PECAM-1
Note	This CD31/PECAM1 antibody (clone MEC 7.46) is useful for Immunoprecipitation, Immunohistochemistry on frozen sections, Flow Cytometry and Immunofluorescence.
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways	Cell adhesion molecules (CAMs), Leukocyte transendothelial migration

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