TRPM5 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Mouse heart tissue IHC: 50-200 Positive control: Human thyroid cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 1029-1043 amino acids of human transient receptor potential cation channel, subfamily M, member 5
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	transient receptor potential cation channel subfamily M member 5
Database Link	NP_055370 Entrez Gene 56843 MouseEntrez Gene 29850 Human UniProt ID Q9NZQ8
Background	This gene encodes a member of the transient receptor potential (TRP) protein family; which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction; and has characteristics of a calcium-activated; non-selective cation channel that carries Na+; K+; and Cs+ ions equally well; but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+); and inhibited by higher concentrations. It is also a highly temperature-sensitive; heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5; and has been shown to be imprinted; with exclusive expression from the paternal allele.
Synonyms	LTRPC5; MTR1
Reference Data
Protein Families	Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane
Protein Pathways	Taste transduction

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