Claudin 1 (CLDN1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1000-3000 WB positive control: Hela cells IHC: 100-300 Positive control: Human esophagus cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 196-209 amino acids of Human claudin 1
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	23 kDa
Gene Name	claudin 1
Database Link	NP_066924 Entrez Gene 12737 MouseEntrez Gene 65129 RatEntrez Gene 9076 Human UniProt ID O95832
Background	Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets; forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet; with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene; a member of the claudin family; is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.
Synonyms	CLD1; ILVASC; SEMP1
Reference Data
Protein Families	Transmembrane
Protein Pathways	Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Tight junction

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