Serine Palmitoyltransferase (SPTLC2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	SPT2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human SPT2.
Formulation	SPT2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	SPT2 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	serine palmitoyltransferase long chain base subunit 2
Database Link	NP_004854 Entrez Gene 20773 MouseEntrez Gene 366697 RatEntrez Gene 9517 Human UniProt ID O15270
Background	SPT2 Antibody: Serine palmitoyltransferase (SPT), which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. SPT2 is the long chain base subunit 2 of mammalian serine palmitoyltransferase. SPT2 is catalytically active but needs its related protein SPT1 for its stabilization and anchoring the holoenzyme to the cytosolic face of the endoplasmic reticulum. As in the case with SPT1, mutations in the SPT2 gene can cause hereditary sensory and autonomic neuropathy type I (HSAN-I), resulting from a loss of SPT activity as well as the accumulation of the atypical and neurotoxic sphingoid metabolite 1-deoxy-sphinganine.
Synonyms	hLCB2a; HSN1C; LCB2; LCB2A; NSAN1C; SPT2
Reference Data
Protein Pathways	Metabolic pathways, Sphingolipid metabolism

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