OGT Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	IHC:1:100-1:1000; WB:1:500-1:3000
Reactivity	Human, Mouse, Rat, Xenopus, Pig, Bovine, X. tropicalis
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant fragment corresponding to a region within amino acids 1 and 280 of O-GlcNAc transferase (Uniprot ID#O15294)
Formulation	0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration	lot specific
Purification	Purified by antigen-affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	116 kDa
Gene Name	O-linked N-acetylglucosamine (GlcNAc) transferase
Database Link	NP_858059 Entrez Gene 26295 RatEntrez Gene 108155 MouseEntrez Gene 8473 Human UniProt ID O15294
Background	O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains nine tetratricopeptide repeats and a putative bipartite nuclear localization signal. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq]
Synonyms	HRNT1; O-GLCNAC
Note	Seq homology of immunogen across species: Rat (100%), Xenopus laevis (100%), Xenopus Tropicalis (100%), Pig (100%), Bovine (100%)
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Metabolic pathways, O-Glycan biosynthesis

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