ACVR1 Sheep Polyclonal Antibody

Specifications

Product Data
Applications	IHC, IP, WB
Recommend Dilution	Western Blot: 5 - 10 µg/ml. Immunoprecipitation: 5 µg/mg of protein lysate. Immunohistochemistry on paraffin sections: 5 - 10 µg/ml.
Reactivity	Chicken
Host	Sheep
Clonality	Polyclonal
Immunogen	Recombinant protein derived from the extracellular domain of the chicken ALK2 protein. Protein shares significant homology with the mouse, rat and human sequences.
Specificity	This antibody reacts to ALK2.
Formulation	Phosphate buffered saline with 0.08% sodium azide State: Purified State: Liquid purified Ig
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only. Avoid repeated freezing and thawing.
Gene Name	activin A receptor, type I
Database Link	Entrez Gene 395246 Chicken UniProt ID Q90ZK6
Background	Activin Receptor-Like Kinase 2 is a member of the superfamily of type I receptors for transforming growth factor-beta (TGF-beta). This receptor binds both activin and bone morphogenic proteins (BMPs). In mice, these receptors are expressed mainly in the extraembryonic visceral endoderm before gastrulation and later in both embryonic and extraembryonic cells during gastrulation. Also, it has been shown that ALK2 associates with and phosphorylates Smad1 and also regulated Smad5 and Smad8 phosphorylation. It also induces the Tlx2 promoter in the absense of BMP7.
Synonyms	Activin receptor type IA, ACVRLK2, ALK2, SKR1, ACRV1A
Reference Data

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