Cd5 Mouse Monoclonal Antibody [Clone ID: HIS47]

CAT#: AM39067SU-N

Cd5 mouse monoclonal antibody, clone HIS47, Supernatant



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CNY 3,939.00


货期*
5周

规格
    • 1 ml

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Specifications

Product Data
Clone Name HIS47
Applications IF, IHC
Recommend Dilution Flow cytometry.
Immunofluorescence.
Immunohistochemistry on frozen sections.
Reactivity Rat
Host Mouse
Clonality Monoclonal
Specificity The antibody recognizes peripheral T lymphocytes and thymocytes (CD5).
In rats, a CD5+ subset of B lymphocytes has not beem characterized.
Formulation State: Supernatant
State: Liquid cell culture supernatant containing 0.09% sodium azide
Conjugation Unconjugated
Storage Condition Store undiluted a 2-8°C.
Gene Name Cd5 molecule
Background CD5 antigen (T1; 67 kDa) is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. CD5 is expressed on all mature T-lymphocytes, most of thymocytes, (human) subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains. The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. Preliminary evidence shows protein associations with ZAP-70, p56lck, p59fyn, PC-PLC, etc. CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor.
CD72 is the major ligand for CD5.
Synonyms CD5, LEU1
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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