Ptprc Mouse Monoclonal Antibody [Clone ID: ANK74]

Specifications

Product Data
Clone Name	ANK74
Applications	IHC
Recommend Dilution	Flow Cytometry.  Immunohistochemistry in Freshly Frozen Sections.
Reactivity	Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	The ANK74 monoclonal antibody was generated by immunizing mice with IL-2-activated cultured NK cells of Wag Rats.
Specificity	This is a Rat strain-independent antibody to CD45. This monoclonal antibody clone ANK74  recognizes a common epitope of Rat CD45, present on all Rat leucocytes.  ANK74 binds CD45. This antigen of approximately 200 kDa is expressed on the cell surface of leucocytes. The antibody is able to modulate lysis of target cells by NK cells (See Giezeman-Smits et al., 1999).
Formulation	State: Supernatant State: Hybridoma Culture Supernatant Preservative: 0.05% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for two months or (in aliquots) at -20°C for longer.  Avoid repeated freezing and thawing.
Gene Name	protein tyrosine phosphatase, receptor type, C
Database Link	Entrez Gene 24699 Rat UniProt ID P04157
Background	CD45 is a family of single chain transmembraneous glycoproteins consisting of at least four isoforms (220, 205, 190, 180 kDa) which share a common large intracellular domain. Their extracellular domains are heavily glycosylated. The different isoforms are produced by alternative messenger RNA splicing of three exons of a single gene on chromosome 1. CD45 is expressed on cells of the human hematopoietic lineage (including hematopoietic stem cells) with the exception of mature red cells. It is not detected on differentiated cells of other tissues. It is likely that CD45 plays an important role in signal transduction, inhibition or upregulation of various immunological functions. Antibodies recognising a common epitope on all of the isoforms are termed CD45 whilst those recognising only individual isoforms are termed CD45RA or CD45RO etc.
Synonyms	PTPRC, Leukocyte common antigen, L-CA, T200
Reference Data

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