CD41 (ITGA2B) Mouse Monoclonal Antibody [Clone ID: 96.2C1]

Specifications

Product Data
Clone Name	96.2C1
Applications	FC, IHC
Recommend Dilution	Immunohistochemistry on frozen sections: 1 μg/ml (1:400). Has been described to work in FACS. Suggested positive control: Human placenta.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody recognizes the CD41 antigen of the CD41/61 complex expressed on platelets and megakaryocytes.
Formulation	Stock solution contains 0.4mg/ml IgG, phosphate buffered saline pH 7.2 (PBS), 5mg/ml bovine serum albumin (BSA), and 0.09% sodium azide as a preservative State: Aff - Purified State: Lyophilized Ig fraction
Reconstitution Method	Reconstitute by adding 0.5ml distilled water.
Purification	Affinity chromatography
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store at 2-8°C. Following reconstitution store (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	integrin subunit alpha 2b
Database Link	Entrez Gene 3674 Human UniProt ID P08514
Background	The CD41/CD61 complex, also known as platelet glycoprotein (GP) IIb/IIIa, or integrin αIIbβ3, mediates platelet aggregation by serving as the receptor for fibrinogen and von Willebrand factor.
Synonyms	Integrin alpha-IIb, GP2B, ITGAB, GPalpha IIb
Note	Antigen, epitope: The antigen is CD41, a 140kD glycoprotein. The epitope has not been further chracterized. Antigen distribution: Isolated cells: The antibody stains >90% of human peripheral blood platelets in flow cytometry. Tissue sections: platelets.
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways	Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Pathways in cancer, Regulation of actin cytoskeleton, Small cell lung cancer

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