Cd8a Rat Monoclonal Antibody [Clone ID: 53-6.7]

CAT#: AM08023RT-N

Cd8a rat monoclonal antibody, clone 53-6.7, PE-TXRD



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CNY 5,071.00


货期*
4周

规格
    • 100 ug

Product images

Specifications

Product Data
Clone Name 53-6.7
Applications FC, IHC, IP
Recommend Dilution Flow Cytometry: < / = 0.22 µg/10e6 cells. (Ref.8,9)
Immunohistochemistry (Acetone-Fixed Frozen Sections) (See Ref. 10)
Immunoprecipitation. (Ref.8)
Fractionation of CD8a+ T cells. (Ref.10)
Reactivity Mouse
Host Rat
Clonality Monoclonal
Specificity This antibody recognises the alpha chain of the Murine CD8 hetrerodimer (Mr. 32-34 kDa).
Formulation PBS containing 0.09% Sodium Azide as preservative and a stabilizing agent.
Label: PE-TXRD
State: Liquid purified Ig fraction.
Label: R-Phycoerythrin-Texas Red
Concentration lot specific
Conjugation PE-TXRD
Storage Condition Store the antibody undiluted at 2-8°C.
DO NOT FREEZE!
This product is photosensitive and should be protected from light.
Avoid repeated freezing and thawing.
Gene Name CD8 antigen, alpha chain
Background In the mouse, CD8 exists in two forms: (i) a CD8 heterodimer composed of an alpha chain (CD8a/Lyt-2) and a beta chain (CD8b/Lyt-3); and (ii) a homodimer of two alpha chains. The heterodimer is found on the surface of essentially all thymocytes and the ''suppressor/cytotoxic'' subpopulation of mature T lymphocytes. Subsets of intestinal intraepithelial lymphocytes express CD8a without CD8b. It has been suggested that CD8+b- T cells mature extrathymically, while development of the CD8a+b+ population of T cells is thymus-dependent. CD8 acts as a coreceptor with MHC Class I-restricted T cell receptors in antigen recognition and positive selection of MHC class I-restricted CD8+ T cells.
In vivo and in vitro treatment with the 53-6.7 monoclonal antibody effectively depletes CD8a+ cells. The 53-6.7 monoclonal antibody also blocks allogeneic help specific for class I MHC antigens and T cell responses to IL-2. (Ref. 1-8)
Synonyms CD8 alpha chain, CD8A, MAL
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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