TYRO3 Mouse Monoclonal Antibody [Clone ID: 6D6F10]

Specifications

Product Data
Clone Name	6D6F10
Applications	ELISA, IF
Recommend Dilution	ELISA: 1/10000. Immunofluorescence: 1/200 - 1/1000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of Tyro3 (aa138-321) expressed in E. Coli.
Specificity	Recognizes Tyro3 (also known as Sky and Rse).
Formulation	State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	TYRO3 protein tyrosine kinase
Database Link	Entrez Gene 7301 Human UniProt ID Q06418
Background	Tyro3 (also known as Sky and Rse), with 890-amino acid protein (about 98kDa), belongs to the Axl/Tyro3 family of receptor tyrosine kinases, which also includes Axl and Mer.Gas6 (growth arrest-specific gene-6) is a ligand for all members of the Axl family and they play essential roles in spermatogenesis, immunoregulation, and phagocytosis.Tyro3 was expressed at high levels during postnatal development and in the adult in the cortex.Tyro3 and Gas6 have neurotrophic roles in the nervous system.In addition, the signalling interactions of Axl and Tyro3 may play roles in tumourigenesis, inflammation as well as other cell proliferative diseases.
Synonyms	BYK, DTK, RSE, SKY
Reference Data

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