Over-expression Lysates

Proteins

Over-expression Lysates

Human

HER2

PTCH1

WNT10A

AKT3

ARNT

B RAF

BETA CATENIN

BIRC2

CCND1

CD117

CDC42

CDH1

CDK4

CKS1B

CRKL

E2F1

EGFR

FGF5

FOXO1

GLUCOSE TRANSPORTER GLUT1

HDAC2

HIF1A

IGF1R

ITGA6

ITGB1

KAT3A / CBP

KRAS

LEF1

MCSF RECEPTOR

MDM2

MITF

MMP1

MYC

P53

PAX8

PTEN

PTK2

RAC2

RASSF5

RUNX1

SMAD4

STAT5B

TCF7

TP53

TRAF6

VEGFC

VHL

WNT5A

HEK293T

C-Myc/DDK

Druggable Genome

Transcription Factors

ES Cell Differentiation/IPS

Transmembrane

Protein Kinase

Secreted Protein

Stem cell - Pluripotency

Adult stem cells

Stem cell relevant signaling - JAK/STAT signaling pathway

Stem cell relevant signaling - Wnt Signaling pathway

Cancer stem cells

Embryonic stem cells

Induced pluripotent stem cells

Phosphatase

Protease

Stem cell relevant signaling - DSL/Notch pathway

Stem cell relevant signaling - TGFb/BMP signaling pathway

Pathways in cancer

Metabolic pathways

Focal adhesion

MAPK signaling pathway

Regulation of actin cytoskeleton

Endocytosis

Prostate cancer

Cytokine-cytokine receptor interaction

Endometrial cancer

Wnt signaling pathway

Chemokine signaling pathway

Insulin signaling pathway

Bladder cancer

Cell cycle

Chronic myeloid leukemia

Adherens junction

Axon guidance

Fc gamma R-mediated phagocytosis

Melanoma

Neuroactive ligand-receptor interaction

Non-small cell lung cancer

Pancreatic cancer

Colorectal cancer

Neurotrophin signaling pathway

Small cell lung cancer

Ubiquitin mediated proteolysis

p53 signaling pathway

Cell adhesion molecules (CAMs)

ErbB signaling pathway

Melanogenesis

Renal cell carcinoma

Glioma

Huntington's disease

Leukocyte transendothelial migration

T cell receptor signaling pathway

Calcium signaling pathway

Thyroid cancer

Tight junction

Acute myeloid leukemia

Basal cell carcinoma

Jak-STAT signaling pathway

TGF-beta signaling pathway

Alzheimer's disease

Apoptosis

Hematopoietic cell lineage

Lysosome

Natural killer cell mediated cytotoxicity

PPAR signaling pathway

Fc epsilon RI signaling pathway

Glycolysis / Gluconeogenesis

Oocyte meiosis

Progesterone-mediated oocyte maturation

VEGF signaling pathway

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

ECM-receptor interaction

Long-term potentiation

Metabolism of xenobiotics by cytochrome P450

Notch signaling pathway

B cell receptor signaling pathway

Parkinson's disease

Prion diseases

Toll-like receptor signaling pathway

mTOR signaling pathway

Dorso-ventral axis formation

Epithelial cell signaling in Helicobacter pylori infection

Fructose and mannose metabolism

Hedgehog signaling pathway

NOD-like receptor signaling pathway

Pathogenic Escherichia coli infection

Purine metabolism

Spliceosome

Vascular smooth muscle contraction

Viral myocarditis

Adipocytokine signaling pathway

Amyotrophic lateral sclerosis (ALS)

Antigen processing and presentation

Base excision repair

Citrate cycle (TCA cycle)

Glutathione metabolism

Glycosaminoglycan degradation

GnRH signaling pathway

Hypertrophic cardiomyopathy (HCM)

Long-term depression

Maturity onset diabetes of the young

Systemic lupus erythematosus

Type I diabetes mellitus

Type II diabetes mellitus

Vibrio cholerae infection

Alanine

Butanoate metabolism

Cardiac muscle contraction

Complement and coagulation cascades

Cysteine and methionine metabolism

Cytosolic DNA-sensing pathway

DNA replication

Dilated cardiomyopathy

Drug metabolism - cytochrome P450

Gap junction

Glycosphingolipid biosynthesis - lacto and neolacto series

Inositol phosphate metabolism

Oxidative phosphorylation

Phosphatidylinositol signaling system

Primary immunodeficiency

Pyruvate metabolism

RIG-I-like receptor signaling pathway

aspartate and glutamate metabolism

ABC transporters

Amino sugar and nucleotide sugar metabolism

Androgen and estrogen metabolism

Arachidonic acid metabolism

Arginine and proline metabolism

Autoimmune thyroid disease

Biosynthesis of unsaturated fatty acids

C21-Steroid hormone metabolism

Drug metabolism - other enzymes

Galactose metabolism

Graft-versus-host disease

Histidine metabolism

Nucleotide excision repair

Pentose phosphate pathway

Phenylalanine metabolism

Proteasome

Renin-angiotensin system

Retinol metabolism

Ribosome

SNARE interactions in vesicular transport

Sphingolipid metabolism

Starch and sucrose metabolism

Synthesis and degradation of ketone bodies

Tryptophan metabolism

Tyrosine metabolism

Valine

leucine and isoleucine degradation

Aminoacyl-tRNA biosynthesis

Asthma

Basal transcription factors

Chondroitin sulfate biosynthesis

Ether lipid metabolism

Fatty acid metabolism

Glycerolipid metabolism

Glycine

Glycosphingolipid biosynthesis - globo series

Glyoxylate and dicarboxylate metabolism

Linoleic acid metabolism

Lysine degradation

Nicotinate and nicotinamide metabolism

O-Mannosyl glycan biosynthesis

One carbon pool by folate

Pantothenate and CoA biosynthesis

Pentose and glucuronate interconversions

Primary bile acid biosynthesis

Propanoate metabolism

Pyrimidine metabolism

RNA degradation

Regulation of autophagy

Taurine and hypotaurine metabolism

Terpenoid backbone biosynthesis

beta-Alanine metabolism

leucine and isoleucine biosynthesis

serine and threonine metabolism

1

Yes