Activin A Receptor Type IB (ACVR1B) Human shRNA Plasmid Kit (Locus ID 91)

Specifications

Product Data
Product Name	Activin A Receptor Type IB (ACVR1B) Human shRNA Plasmid Kit (Locus ID 91)
Locus ID	91
UniProt ID	P36896
Synonyms	ACTRIB; ACVRLK4; ALK4; SKR2
Vector	pRFP-C-RS
Format	Retroviral plasmids
Kit Components	ACVR1B - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 91). 5µg purified plasmid DNA per construct 29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free.
RefSeq	NM_004302, NM_020327, NM_020328, NM_004302.1, NM_004302.2, NM_004302.3, NM_004302.4, NM_020328.1, NM_020328.2, NM_020328.3, NM_020327.1, NM_020327.2, NM_020327.3, BC040531, BC040531.1, BC000254, BC034008, NM_020328.4, NM_004302.5
Summary	This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]
shRNA Design	These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Performance Guaranteed	OriGene guarantees that the sequences in the shRNA expression cassettes are verified to correspond to the target gene with 100% identity. One of the four constructs at minimum are guaranteed to produce 70% or more gene expression knock-down provided a minimum transfection efficiency of 80% is achieved. Western Blot data is recommended over qPCR to evaluate the silencing effect of the shRNA constructs 72 hrs post transfection. To properly assess knockdown, the gene expression level from the included scramble control vector must be used in comparison with the target-specific shRNA transfected samples. For non-conforming shRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the shRNA kit. To arrange for a free replacement with newly designed constructs, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled shRNA control (Western Blot data preferred).

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.