TNFRSF13C (1-78, hIgG-Tag) Human Recombinant Protein

Specifications

Product Data
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) MRRGPRS LRGRDAPAPT PCVPAECFDL LVRHCVACGL LRTPRPKPAG ASSPAPRTAL QPQESVGAGA GEAALPLPGL L
Tag	hIgG-Tag
Predicted MW	34.4kDa (314aa)
Concentration	1mg/ml (determined by Absorbance at 280nm)
Purity	> 95% by SDS-PAGE
Buffer	Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Applications	SDS-PAGE, Bioactivity
Storage	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Bioactivity	Measured by its binding ability in a functional ELISA with Human BAFF (CAT# ATGP4139). The ED50 range ≤ 0.7 ug/ml.
Endotoxin	< 1 EU per 1ug of protein (determined by LAL method)
Reference Data
RefSeq	NP_443177.1
Summary	BAFFR, also known as TNFRSF13C, is a member of the tumor necrosis factor receptor superfamily. Members of the TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity and in cellular apoptosis process. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL, BAFFR selectively binds BAFF. The BAFFR extracellular domain lacks the CRD (TNF receptor canonical cysteine-rich domain and contains only a partial CRD with four cysteine residues. It is highly expressed in spleen, lymph node and resting B cells and is thought the principal receptor required for BAFF-mediated mature B-cell survival. It has been proposed that abnormally high levels of BAFFR may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. Recombinant human BAFFR, fused to hIgG-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

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