Il23a Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Protein Source	Baculovirus
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Val22-Ala196&Met23-Ser335
Buffer	Lyophilized from a 0.2 um filtered solution of PBS,pH7.4.
Note	Recombinant Mouse Interleukin-23 is produced by our Baculovirus expression system and the target gene encoding Val22-Ala196&Met23-Ser335 is expressed.
Stability	12 months from date of despatch
Reference Data
Locus ID	83430
UniProt ID	Q9EQ14
Summary	Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naive and memory human T cells, the effects of IL-23 is restricted to memory T cells.

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