CD117 Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Gln26-Thr520
Tag	C-His
Buffer	Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
Note	Biotinylated Recombinant Human Mast/stem Cell Growth Factor Receptor Kit is produced by our mammalian expression system and the target gene encoding Gln26-Thr520 is expressed with a His tag at the C-terminus.
Stability	12 months from date of despatch
Reference Data
Locus ID	3815
UniProt ID	P10721
Summary	C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. Mature human SCF R consists of a 499 amino acid (aa) extracellular domain (ECD) with five tandem immunoglobulinlike domains, a 21 aa transmembrane segment, and a 431 aa cytoplasmic domain with the split tyrosine kinase domain. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up-regulated on dendritic cells by Th2-or Th17-biasing stimuli, and it is required for subsequent dendritic cell induction of Th2 and Th17 responses. SCF R protects vascular smooth muscle cells from apoptosis and assists in the recovery of cardiac function following myocardial infarction.

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