Eph receptor A2 (EPHA2) Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Ala24-Asn534
Tag	C-hFc
Buffer	Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4
Note	Recombinant Human EphA2 is produced by our Mammalian expression system and the target gene encoding Ala24-Asn534 is expressed with a hFc tag at the C-terminus.
Stability	12 months from date of despatch
Reference Data
Locus ID	1969
UniProt ID	P29317
Summary	Ephrin type-A receptor 2 (EphA2) belongs to the Eph receptor tyrosine kinase family which binds Ephrins A1, 2, 3, 4, and 5. The ephrins and Eph receptors are implicated as positional labels that may guide the development of neural topographic maps. They have also been found involved in embryonic patterning, neuronal targeting, vascular development and adult neovascularization. Furthermore, elevated expression of Eph receptors and ephrin ligands is associated with tumors and associated tumor vasculature, suggesting the Eph receptors and ephrin ligands also play critical roles in tumor angiogenesis and tumor growth. EphA2 is upregulated in breast, prostate, and colon cancer vascular endothelium. Its ligand, EphrinA1, is expressed by the local tumor cells. In some cases, EphA2 and EphrinA1 are expressed in the same blood vessels. EphA2 signaling cooperates with VEGF receptor signaling in promoting endothelial cell migration.

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