Apoe Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Glu19-Gln311
Tag	C-6His
Buffer	Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, 0.1%Tween 80, 10% trehalose, pH 7.4
Note	Recombinant Mouse Apolipoprotein E is produced by our Mammalian expression system and the target gene encoding Glu19-Gln311 is expressed with a 6His tag at the C-terminus.
Stability	12 months from date of despatch
Reference Data
Locus ID	11816
UniProt ID	P08226
Summary	Apolipoprotein E (ApoE) is a glycoprotein that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. ApoE can be synthesized by the liver and intestinally synthesized chylomicrons. ApoE mediates high-affinity binding of chylomicrons and very low density lipoprotein (VLDL) particles to the LDL receptor, allowing for specific uptake of these particles by the liver, preventing the accumulation of cholesterol-rich particles in the plasma. ApoE plays an essential role in the formation of plasma lipoproteins and is involved in their production, conversion and clearance. ApoE is also a constituent of a subclass of high density of lipoproteins (HDL) involved in cholesterol transport. More recently, ApoE has been studied for its role in several biological processes not directly related to lipoprotein transport, including Alzheimer's disease, immunoregulation, and cognition.

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