SGSH Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Arg21-Leu502
Tag	C-6His
Buffer	Supplied as a 0.2 um filtered solution of 20mM TrisHCl,150mM NaCl,1mM GaCl2,10%Glycerol,pH7.5.
Note	Recombinant Human N-Sulphoglucosamine Sulphohydrolase is produced by our Mammalian expression system and the target gene encoding Arg21-Leu502 is expressed with a 6His tag at the C-terminus.
Stability	12 months from date of despatch
Reference Data
Locus ID	6448
UniProt ID	P51688
Summary	N-Sulphoglucosamine Sulphohydrolase (SGSH) is a member of the sulfatase family that is involved in the degradation of heparin sulfate (HS). SGSH catalyzes N-sulfo-D-glucosamine and H2O to D-glucosamine and sulfate. Unlike the HS specific endosulfatases that remove sulfate from internal GlcNAc residues, SGSH removes sulfate group from the non-reducing end glucosamine residues on HS. SGSH leads to mucopolysaccharidosis type 3A (MPS3A), a recessive lysosomal storage disease characterized by neurological dysfunction but relatively mild somatic manifestations.

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