Her2 (ERBB2) Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) T23-T652
Tag	C-6His
Buffer	Lyophilized from a 0.2 um filtered solution of PBS, pH7.4
Note	Recombinant human ErbB2 is produced by Human 293 Cells. The target gene encoding T23-T652 is expressed with a 6His tag at the C terminus.
Stability	12 months from date of despatch
Reference Data
Locus ID	2064
UniProt ID	P04626
Summary	ErbB2, also known as human epidermal growth factor receptor 2 (HER2), is a type I membrane glycoprotein that belongs to the epidermal growth factor (EGF) receptor family. ErbB2 is expressed in various tumor tissue including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth. ErbB2 plays a key role in development, cell proliferation and differentiation. ErbB2 is reported to be an orphan receptor, with none of the EGF family of ligands able to activate it. Around 30% of breast cancers overexpress ErbB2, which is associated with increased disease recurrence and worse prognosis.

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