Antithrombin III (SERPINC1) (NM_000488) Human Mass Spec Standard

CAT#: PH322845

SERPINC1 MS Standard C13 and N15-labeled recombinant protein (NP_000479)



  View other "Antithrombin III" proteins (3)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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经常一起买 (2)
Transient overexpression lysate of serpin peptidase inhibitor, clade C (antithrombin), member 1 (SERPINC1)
    • 100 ug

CNY 4,840.00


SERPINC1 (Antithrombin III) mouse monoclonal antibody, clone OTI8D5 (formerly 8D5)
    • 100 ul

CNY 1,999.00
CNY 2,700.00

Specifications

Product Data
Description SERPINC1 MS Standard C13 and N15-labeled recombinant protein (NP_000479)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC222845
Predicted MW 52.6 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_000479
RefSeq Size 1559
RefSeq ORF 1392
Synonyms AT3; AT3D; ATIII; ATIII-R2; ATIII-T1; ATIII-T2; THPH7
Locus ID 462
Cytogenetics 1q25.1
Summary The protein encoded by this gene, antithrombin III, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. Numerous mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency which constitutes a strong risk factor for thrombosis. A reduction in the serum level of this protein is associated with severe cases of Coronavirus Disease 19 (COVID-19). [provided by RefSeq, Sep 2020]
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Complement and coagulation cascades
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