TrkA (NTRK1) (NM_001012331) Human Mass Spec Standard

CAT#: PH313091

NTRK1 MS Standard C13 and N15-labeled recombinant protein (NP_001012331)



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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description NTRK1 MS Standard C13 and N15-labeled recombinant protein (NP_001012331)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC213091
Predicted MW 86.7 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_001012331
RefSeq Size 2647
RefSeq ORF 2370
Synonyms MTC; p140-TrkA; TRK; Trk-A; TRK1; TRKA
Locus ID 4914
Cytogenetics 1q23.1
Summary This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways Apoptosis, Endocytosis, MAPK signaling pathway, Neurotrophin signaling pathway, Pathways in cancer, Thyroid cancer
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