BIN1 (NM_139350) Human Mass Spec Standard

CAT#: PH302423

BIN1 MS Standard C13 and N15-labeled recombinant protein (NP_647600)



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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description BIN1 MS Standard C13 and N15-labeled recombinant protein (NP_647600)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC202423
Predicted MW 48.3 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_647600
RefSeq Size 2224
RefSeq ORF 1317
Synonyms AMPH2; AMPHL; CNM2; SH3P9
Locus ID 274
Cytogenetics 2q14.3
Summary This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Mar 2016]
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